UDP-Glucuronosyltransferase-mediated Metabolic Activation of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole

2-Amino-9H-pyrido[2,3-b]indole (AαC) is a carcinogenic heterocyclic aromatic amine (HAA) that arises in tobacco smoke. UDP-glucuronosyltransferases (UGTs) are important enzymes that detoxicate many procarcinogens, including HAAs. UGTs compete with P450 enzymes, which bioactivate HAAs by N-hydroxylat...

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Veröffentlicht in:	The Journal of biological chemistry 2012-04, Vol.287 (18), p.14960-14972
Hauptverfasser:	Tang, Yijin, LeMaster, David M., Nauwelaërs, Gwendoline, Gu, Dan, Langouët, Sophie, Turesky, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbolines - chemistry Carbolines - pharmacokinetics Carcinogens - chemistry Carcinogens - pharmacokinetics Female Glucuronosyltransferase - chemistry Glucuronosyltransferase - genetics Glucuronosyltransferase - metabolism Heterocyclic Aromatic Amine Humans Hydrogen-Ion Concentration Life Sciences Male Mass Spectrometry (MS) Metabolism Microsomes, Liver - enzymology Nuclear Magnetic Resonance Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Tobacco Carcinogen Toxicology UDP-glucuronosyltransferase UDP-Glucuronosyltransferase 1A9 Xenobiotics
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