Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication

We have discovered that 3,3′,5-triiodothyronine (T3) inhibits binding of a PIP-box sequence peptide to proliferating cell nuclear antigen (PCNA) protein by competing for the same binding site, as evidenced by the co-crystal structure of the PCNA-T3 complex at 2.1 Å resolution. Based on this observat...

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Veröffentlicht in:	The Journal of biological chemistry 2012-04, Vol.287 (17), p.14289-14300
Hauptverfasser:	Punchihewa, Chandanamali, Inoue, Akira, Hishiki, Asami, Fujikawa, Yoshihiro, Connelly, Michele, Evison, Benjamin, Shao, Youming, Heath, Richard, Kuraoka, Isao, Rodrigues, Patrick, Hashimoto, Hiroshi, Kawanishi, Masanobu, Sato, Mamoru, Yagi, Takashi, Fujii, Naoaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer Drug Chemical Biology Chemistry, Pharmaceutical - methods Chromatin - metabolism Crystallography Crystallography, X-Ray - methods DNA and Chromosomes DNA Repair DNA Replication DNA Replication - physiology Drug Design Flow Cytometry - methods Genes, Reporter HeLa Cells Humans Inhibitory Concentration 50 Ligands Microscopy, Fluorescence - methods Molecular Conformation PCNA Peptides - chemistry Phosphorylation Proliferating Cell Nuclear Antigen - metabolism Protein Interaction Mapping - methods Protein-Protein Interactions Recombinant Proteins - chemistry Small Molecule Translesion Synthesis
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