Biosynthesis of Threonylcarbamoyl Adenosine (t6A), a Universal tRNA Nucleoside

The anticodon stem-loop (ASL) of transfer RNAs (tRNAs) drives decoding by interacting directly with the mRNA through codon/anticodon pairing. Chemically complex nucleoside modifications found in the ASL at positions 34 or 37 are known to be required for accurate decoding. Although over 100 distinct...

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Veröffentlicht in:	The Journal of biological chemistry 2012-04, Vol.287 (17), p.13666-13673
Hauptverfasser:	Deutsch, Christopher, El Yacoubi, Basma, de Crécy-Lagard, Valérie, Iwata-Reuyl, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - chemistry Anticodon Archaea Bacteria Base Sequence Bioinformatics Biosynthesis Carboxylation Catalysis Codon Computational Biology - methods Enzyme Catalysis Enzyme Mechanisms Enzymology Escherichia coli - metabolism Escherichia coli - physiology Escherichia coli Proteins - metabolism Gene Expression Regulation, Bacterial Mass Spectrometry - methods Molecular Sequence Data Nucleic Acid Conformation Protein Binding Protein Complexes Recombinant Proteins - chemistry RNA Modification RNA, Transfer - chemistry RNA, Transfer - metabolism RNA-Binding Proteins - metabolism Transfer RNA (tRNA)
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