Novel Phenol-soluble Modulin Derivatives in Community-associated Methicillin-resistant Staphylococcus aureus Identified through Imaging Mass Spectrometry

Staphylococcus aureus causes a wide range of human disease ranging from localized skin and soft tissue infections to potentially lethal systemic infections. S. aureus has the biosynthetic ability to generate numerous virulence factors that assist in circumventing the innate immune system during dise...

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Veröffentlicht in:	The Journal of biological chemistry 2012-04, Vol.287 (17), p.13889-13898
Hauptverfasser:	Gonzalez, David J., Okumura, Cheryl Y., Hollands, Andrew, Kersten, Roland, Akong-Moore, Kathryn, Pence, Morgan A., Malone, Cheryl L., Derieux, Jaclyn, Moore, Bradley S., Horswill, Alexander R., Dixon, Jack E., Dorrestein, Pieter C., Nizet, Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anti-Infective Agents - pharmacology Bacteria Bacterial Infections Bacterial Infections - metabolism Bacterial Proteins - chemistry Bacterial Toxins Bacterial Toxins - chemistry Erythrocytes - cytology Hemolysis Humans Imaging Mass Spectrometry Immunosuppressive Agents - pharmacology Mass Spectrometry (MS) Mass Spectrometry - methods Metalloendopeptidases - chemistry Methicillin-Resistant Staphylococcus aureus - metabolism Mice Microbiology Molecular Sequence Data Neutrophils - cytology Neutrophils - metabolism Phenol - chemistry Phenol-soluble Modulins (PSMs) Sequence Homology, Amino Acid Sheep Skin - metabolism Skin - microbiology Staphylococcal Skin Infections - microbiology Staphylococcus aureus Virulence Factors Virulence Factors - chemistry
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