myo-Inositol Uptake Is Essential for Bulk Inositol Phospholipid but Not Glycosylphosphatidylinositol Synthesis in Trypanosoma brucei

myo-Inositol is an essential precursor for the production of inositol phosphates and inositol phospholipids in all eukaryotes. Intracellular myo-inositol is generated by de novo synthesis from glucose 6-phosphate or is provided from the environment via myo-inositol symporters. We show that in Trypan...

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Veröffentlicht in:	The Journal of biological chemistry 2012-04, Vol.287 (16), p.13313-13323
Hauptverfasser:	Gonzalez-Salgado, Amaia, Steinmann, Michael E., Greganova, Eva, Rauch, Monika, Mäser, Pascal, Sigel, Erwin, Bütikofer, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics Carrier Proteins - metabolism Down-Regulation - physiology Genes, Protozoan - physiology Glycosylphosphatidylinositol Anchors Glycosylphosphatidylinositols - biosynthesis Golgi Inositol - metabolism Inositol Phospholipid Lipids Membrane Lipids Oocytes - physiology Phenotype Phosphatidylinositol Phosphatidylinositols - biosynthesis Phospholipid Metabolism Phylogeny RNA Interference RNA Interference (RNAi) RNA, Protozoan - metabolism Transporters Tritium Trypanosoma brucei Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - growth & development Trypanosoma brucei brucei - metabolism Xenopus
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