Novel Bacterial Lipoprotein Structures Conserved in Low-GC Content Gram-positive Bacteria Are Recognized by Toll-like Receptor 2

Bacterial lipoproteins/lipopeptides inducing host innate immune responses are sensed by mammalian Toll-like receptor 2 (TLR2). These bacterial lipoproteins are structurally divided into two groups, diacylated or triacylated lipoproteins, by the absence or presence of an amide-linked fatty acid. The...

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Veröffentlicht in:	The Journal of biological chemistry 2012-04, Vol.287 (16), p.13170-13181
Hauptverfasser:	Kurokawa, Kenji, Ryu, Kyoung-Hwa, Ichikawa, Rie, Masuda, Akiko, Kim, Min-Su, Lee, Hanna, Chae, Jun-Ho, Shimizu, Takashi, Saitoh, Tatsuya, Kuwano, Koichi, Akira, Shizuo, Dohmae, Naoshi, Nakayama, Hiroshi, Lee, Bok Luel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacillus cereus - immunology Bacillus cereus - metabolism Bacillus subtilis - immunology Bacillus subtilis - metabolism Enterococcus faecalis - immunology Enterococcus faecalis - metabolism Geobacillus - immunology Geobacillus - metabolism Gram-positive Bacteria Gram-Positive Bacteria - immunology Gram-Positive Bacteria - metabolism Host-Pathogen Interactions Immunology Innate Immunity Lactobacillus - immunology Lactobacillus - metabolism Lipoprotein Low-GC Content Macrophages, Peritoneal - immunology Macrophages, Peritoneal - microbiology Mass Spectrometry (MS) Mice Mice, Inbred C57BL Pneumonia, Mycoplasma - immunology Pneumonia, Mycoplasma - metabolism Streptococcus sanguis - immunology Streptococcus sanguis - metabolism Toll-Like Receptor 1 - genetics Toll-Like Receptor 1 - immunology Toll-Like Receptor 1 - metabolism Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - immunology Toll-Like Receptor 2 - metabolism Toll-Like Receptor 6 - genetics Toll-Like Receptor 6 - immunology Toll-Like Receptor 6 - metabolism Toll-like Receptors (TLR)
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