Caspar-like Gene Depletion Reduces Leishmania Infection in Sand Fly Host Lutzomyia longipalpis

Female phlebotomine sand flies Lutzomyia longipalpis naturally harbor populations of the medically important Leishmania infantum (syn. Leishmania chagasi) parasite in the gut, but the extent to which the parasite interacts with the immune system of the insect vector is unknown. To investigate the sa...

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Veröffentlicht in:	The Journal of biological chemistry 2012-04, Vol.287 (16), p.12985-12993
Hauptverfasser:	Telleria, Erich L., Sant'Anna, Maurício R.V., Ortigão-Farias, João R., Pitaluga, André N., Dillon, Viv M., Bates, Paul A., Traub-Csekö, Yara M., Dillon, Rod J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Animals Caspar Drosophila - genetics Drosophila Proteins - genetics Drosophila Proteins - immunology Female Gastrointestinal Tract - immunology Gastrointestinal Tract - parasitology Genes, Insect - immunology Gut Immunity, Innate - immunology Immunology Innate Immunity Insect Immunity Leishmania Leishmania infantum - growth & development Leishmania infantum - immunology Leishmania mexicana - growth & development Leishmania mexicana - immunology Leishmaniasis, Visceral - immunology Lutzomyia Parasitology Phylogeny Psychodidae - genetics Psychodidae - immunology Psychodidae - parasitology RNA Interference (RNAi) Sand Fly
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