CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and Degradation

The mitotic checkpoint gene CHFR (checkpoint with forkhead-associated (FHA) and RING finger domains) is silenced by promoter hypermethylation or mutated in various human cancers, suggesting that CHFR is an important tumor suppressor. Recent studies have reported that CHFR functions as an E3 ubiquiti...

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Veröffentlicht in:	The Journal of biological chemistry 2012-04, Vol.287 (16), p.12975-12984
Hauptverfasser:	Kashima, Lisa, Idogawa, Masashi, Mita, Hiroaki, Shitashige, Miki, Yamada, Tesshi, Ogi, Kazuhiro, Suzuki, Hiromu, Toyota, Minoru, Ariga, Hiroyoshi, Sasaki, Yasushi, Tokino, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms Cancer Therapy Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Cycle Cell Cycle Checkpoints - physiology Checkpoint Control CHFR Drug Design E3 Ubiquitin Ligase Female Genes, Tumor Suppressor - physiology HEK293 Cells HeLa Cells Humans Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology M Phase Cell Cycle Checkpoints - physiology Male Mice Mice, Inbred C57BL Mice, Knockout Microtubules - drug effects Microtubules - physiology Molecular Bases of Disease Mouth Neoplasms - drug therapy Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Neoplasms, Squamous Cell - drug therapy Neoplasms, Squamous Cell - metabolism Neoplasms, Squamous Cell - pathology PARP Inhibitor PARP-1 Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - metabolism Poly-ADP-Ribose Binding Proteins Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Tumor Suppressor Gene Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination - physiology
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