Myocilin Interacts with Syntrophins and Is Member of Dystrophin-associated Protein Complex

Genetic studies have linked myocilin to open angle glaucoma, but the functions of the protein in the eye and other tissues have remained elusive. The purpose of this investigation was to elucidate myocilin function(s). We identified α1-syntrophin, a component of the dystrophin-associated protein com...

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Veröffentlicht in:	The Journal of biological chemistry 2012-04, Vol.287 (16), p.13216-13227
Hauptverfasser:	Joe, Myung Kuk, Kee, Changwon, Tomarev, Stanislav I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt PKB Animals Calcium-Binding Proteins - metabolism Cell Biology Cell Differentiation - physiology Cytoplasm - metabolism Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Dystrophin Dystrophin - metabolism Eye Eye Proteins - genetics Eye Proteins - metabolism Gene Expression - physiology Glaucoma Glycoproteins - genetics Glycoproteins - metabolism Hypertrophy - metabolism Membrane Proteins - metabolism Mice Mice, Transgenic Mouse Multiprotein Complexes - metabolism Muscle Hypertrophy Muscle Proteins - metabolism Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Muscular Atrophy - metabolism Myoblasts - cytology Myoblasts - metabolism Myocilin Protein Assembly Signal Transduction - physiology Skeletal Muscle Syntrophin Up-Regulation - physiology
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