Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPTI)

Force generation in smooth muscle is driven by phosphorylation of myosin light chains (MYL), which is regulated by the equilibrium between the activities of myosin light chain kinase (MYLK) and myosin phosphatase (MYLP). MYLK is activated by Ca(2+)-calmodulin whereas MYLP is inhibited by phosphoryla...

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Veröffentlicht in:	Molecular human reproduction 2012-05, Vol.18 (5-6), p.265-279
Hauptverfasser:	HUDSON, Claire A, HEESOM, Kate J, BERNAL, Andres López
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Electrophoresis, Polyacrylamide Gel Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Myometrium - drug effects Myometrium - physiology Myosin-Light-Chain Phosphatase - metabolism Nuclear Proteins - metabolism Oxytocics - pharmacology Oxytocin - pharmacology Phosphorylation Pregnancy Promyelocytic Leukemia Protein Protein Isoforms - metabolism rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism Transcription Factors - metabolism Tumor Suppressor Proteins - metabolism Uterine Contraction - drug effects Uterine Contraction - physiology
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