Estrogen Receptor-α Mediates Diethylstilbestrol-Induced Feminization of the Seminal Vesicle in Male Mice

Background: Studies have shown that perinatal exposure to the synthetic estrogen diethylstilbestrol (DES) leads to feminization of the seminal vesicle (SV) in male mice, as illustrated by tissue hyperplasia, ectopic expression of the major estrogen-inducible uterine secretory protein lactoferrin (LF...

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Veröffentlicht in:	Environmental health perspectives 2012-04, Vol.120 (4), p.560-565
Hauptverfasser:	Walker, Vickie R., Jefferson, Wendy N., Couse, John F., Korach, Kenneth S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Androgens Androgens - metabolism Animals Biological and medical sciences Blotting, Western Castration Chemical hazards Diethylstilbestrol - pharmacology Dihydrotestosterone - metabolism Disease Models, Animal Environment. Living conditions Environmental health Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism Estrogens Feminization Feminization - chemically induced Gene Expression Lactoferrin - metabolism Male Males Medical sciences Mice Mice, Knockout Proteins Public health. Hygiene Public health. Hygiene-occupational medicine Radioimmunoassay Real-Time Polymerase Chain Reaction Receptors Receptors, Androgen - metabolism Reproductive tract infections Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Seminal Vesicle Secretory Proteins - metabolism Seminal vesicles Seminal Vesicles - drug effects Seminal Vesicles - metabolism Seminal Vesicles - pathology Testosterone Toxicology Vesicles
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