Formal Synthesis of (−)-Englerin A and Cytotoxicity Studies of Truncated Englerins

An efficient formal synthesis of (−)‐englerin A (1) is reported. The target molecule is a recently isolated guaiane sesquiterpene that possesses highly potent and selective activity against renal cancer cell‐lines. Our enantioselective strategy involved the construction of the BC ring system of comp...

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Veröffentlicht in:	Chemistry, an Asian journal an Asian journal, 2012-05, Vol.7 (5), p.1052-1060
Hauptverfasser:	Xu, Jing, Caro-Diaz, Eduardo J. E., Batova, Ayse, Sullivan, Steven D. E., Theodorakis, Emmanuel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology cancer Catalysis Cell Line, Tumor Cell Proliferation - drug effects Cyclization cycloaddition Humans Inhibitory Concentration 50 Kidney Neoplasms - drug therapy leukemia Models, Molecular natural products Phyllanthus - chemistry Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Rhodium - chemistry Sesquiterpenes, Guaiane - chemical synthesis Sesquiterpenes, Guaiane - chemistry Sesquiterpenes, Guaiane - pharmacology Stereoisomerism total synthesis
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