Eculizumab for Dense Deposit Disease and C3 Glomerulonephritis

The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the alternative complement pathway. Eculizumab, a monoclonal antibody that binds to C5 to prevent formation of the membrane attack complex, may prove beneficial. In this open-label, proof of concept efficacy...

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Veröffentlicht in:	Clinical journal of the American Society of Nephrology 2012-05, Vol.7 (5), p.748-756
Hauptverfasser:	Bomback, Andrew S, Smith, Richard J, Barile, Gaetano R, Zhang, Yuzhou, Heher, Eliot C, Herlitz, Leal, Stokes, M Barry, Markowitz, Glen S, D'Agati, Vivette D, Canetta, Pietro A, Radhakrishnan, Jai, Appel, Gerald B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Complement C5 - antagonists & inhibitors Complement Factor B - genetics Complement Factor H - genetics Complement Factor I - genetics Complement Membrane Attack Complex - metabolism Complement System Proteins - genetics Creatinine - blood Glomerulonephritis, Membranoproliferative - drug therapy Glomerulonephritis, Membranoproliferative - genetics Glomerulonephritis, Membranoproliferative - pathology Humans Male Membrane Cofactor Protein - genetics Original Proteinuria - etiology Proteinuria - urine Young Adult
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