Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy

Quantification of intra-epidermal nerve fibers (iENFs) is an important approach to stage diabetic peripheral neuropathy (DPN) and is a promising clinical endpoint for identifying beneficial therapeutics. Mechanistically, diabetes decreases neuronal mitochondrial function and enhancing mitochondrial...

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Veröffentlicht in:	Experimental neurology 2012-05, Vol.235 (1), p.388-396
Hauptverfasser:	Urban, Michael J., Pan, Pan, Farmer, Kevin L., Zhao, Huiping, Blagg, Brian S.J., Dobrowsky, Rick T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioenergetics Biological and medical sciences Chaperones Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Diabetic Neuropathies - metabolism Diabetic Neuropathies - physiopathology Drugs Epidermis - innervation Fibers Heat shock proteins HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - metabolism Hsp90 protein Intra-epidermal nerve fibers Medical sciences Mice Mitochondria Mitochondria - physiology Molecular Chaperones - metabolism Nerve conduction Nerve conduction velocity Nerve Fibers - physiology Nervous system (semeiology, syndromes) Neural Conduction - physiology Neurology Pain Measurement Peripheral neuropathy Respiration Respiratory capacity Sensory neurons Sensory Receptor Cells - physiology Thermal stimuli
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