Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells
► Mouse splenic macrophages, dendritic cells, and B cells possess functional circadian molecular clocks. In mammals, circadian and daily rhythms influence nearly all aspects of physiology, ranging from behavior to gene expression. Functional molecular clocks have been described in the murine spleen...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2012-03, Vol.26 (3), p.407-413 |
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| creator | Silver, Adam C Arjona, Alvaro Hughes, Michael E Nitabach, Michael N Fikrig, Erol |
| description | ► Mouse splenic macrophages, dendritic cells, and B cells possess functional circadian molecular clocks.
In mammals, circadian and daily rhythms influence nearly all aspects of physiology, ranging from behavior to gene expression. Functional molecular clocks have been described in the murine spleen and splenic NK cells. The aim of our study was to investigate the existence of molecular clock mechanisms in other immune cells. Therefore, we measured the circadian changes in gene expression of clock genes (Per1, Per2, Bmal1, and Clock) and clock-controlled transcription factors (Rev-erbα and Dbp) in splenic enriched macrophages, dendritic cells, and B cells in both mice entrained to a light–dark cycle and under constant environmental conditions. Our study reveals the existence of functional molecular clock mechanisms in splenic macrophages, dendritic cells, and B cells. |
| doi_str_mv | 10.1016/j.bbi.2011.10.001 |
| format | Article |
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In mammals, circadian and daily rhythms influence nearly all aspects of physiology, ranging from behavior to gene expression. Functional molecular clocks have been described in the murine spleen and splenic NK cells. The aim of our study was to investigate the existence of molecular clock mechanisms in other immune cells. Therefore, we measured the circadian changes in gene expression of clock genes (Per1, Per2, Bmal1, and Clock) and clock-controlled transcription factors (Rev-erbα and Dbp) in splenic enriched macrophages, dendritic cells, and B cells in both mice entrained to a light–dark cycle and under constant environmental conditions. Our study reveals the existence of functional molecular clock mechanisms in splenic macrophages, dendritic cells, and B cells.</description><identifier>ISSN: 0889-1591</identifier><identifier>EISSN: 1090-2139</identifier><identifier>DOI: 10.1016/j.bbi.2011.10.001</identifier><identifier>PMID: 22019350</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Allergy and Immunology ; Animals ; ARNTL Transcription Factors - genetics ; ARNTL Transcription Factors - metabolism ; B cells ; B-Lymphocytes - metabolism ; Circadian rhythm ; Circadian Rhythm - genetics ; Circadian Rhythm Signaling Peptides and Proteins - genetics ; CLOCK Proteins - genetics ; CLOCK Proteins - metabolism ; Dendritic cells ; Dendritic Cells - metabolism ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Gene Expression ; Macrophages ; Macrophages - metabolism ; Mice ; Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics ; Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism ; Period Circadian Proteins - genetics ; Period Circadian Proteins - metabolism ; Photoperiod ; Psychiatry ; Spleen - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Brain, behavior, and immunity, 2012-03, Vol.26 (3), p.407-413</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>2012 Elsevier Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-e0e0850afc24369fb5f3337d29f7f7866b7293feda80ccaa9ab246714a3f3e203</citedby><cites>FETCH-LOGICAL-c571t-e0e0850afc24369fb5f3337d29f7f7866b7293feda80ccaa9ab246714a3f3e203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0889159111005617$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22019350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silver, Adam C</creatorcontrib><creatorcontrib>Arjona, Alvaro</creatorcontrib><creatorcontrib>Hughes, Michael E</creatorcontrib><creatorcontrib>Nitabach, Michael N</creatorcontrib><creatorcontrib>Fikrig, Erol</creatorcontrib><title>Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells</title><title>Brain, behavior, and immunity</title><addtitle>Brain Behav Immun</addtitle><description>► Mouse splenic macrophages, dendritic cells, and B cells possess functional circadian molecular clocks.
In mammals, circadian and daily rhythms influence nearly all aspects of physiology, ranging from behavior to gene expression. Functional molecular clocks have been described in the murine spleen and splenic NK cells. The aim of our study was to investigate the existence of molecular clock mechanisms in other immune cells. Therefore, we measured the circadian changes in gene expression of clock genes (Per1, Per2, Bmal1, and Clock) and clock-controlled transcription factors (Rev-erbα and Dbp) in splenic enriched macrophages, dendritic cells, and B cells in both mice entrained to a light–dark cycle and under constant environmental conditions. Our study reveals the existence of functional molecular clock mechanisms in splenic macrophages, dendritic cells, and B cells.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>ARNTL Transcription Factors - genetics</subject><subject>ARNTL Transcription Factors - metabolism</subject><subject>B cells</subject><subject>B-Lymphocytes - metabolism</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - genetics</subject><subject>Circadian Rhythm Signaling Peptides and Proteins - genetics</subject><subject>CLOCK Proteins - genetics</subject><subject>CLOCK Proteins - metabolism</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Gene Expression</subject><subject>Macrophages</subject><subject>Macrophages - metabolism</subject><subject>Mice</subject><subject>Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics</subject><subject>Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism</subject><subject>Period Circadian Proteins - genetics</subject><subject>Period Circadian Proteins - metabolism</subject><subject>Photoperiod</subject><subject>Psychiatry</subject><subject>Spleen - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0889-1591</issn><issn>1090-2139</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk1vEzEQtRCIhsIP4IJ848KGGTv7YSFVgggKUiUOfFwtr3ecOt3Ywd5U9N_jbUoFHDhZM573Zua9Yew5whIBm9fbZd_7pQDEEi8B8AFbICioBEr1kC2g61SFtcIT9iTnLQDUErvH7EQUjJI1LNj3tU_WDN4ETj_3iXL2MfDouB2jveIbCpS5D3wXD5n4ztgU95dmQ_kVHygMyU_eckvjWBImDPzdMXjKHjkzZnp2956ybx_ef11_rC4-n39av72obN3iVBEQdDUYZ8VKNsr1tZNStoNQrnVt1zR9K5R0NJgOrDVGmV6smhZXRjpJAuQpOzvy7g_9jgZLYUpm1Pvkdybd6Gi8_vsn-Eu9ide6tGmwFoXg5R1Bij8OlCe983lewQQqK2slZN2u1G0rPFYWCXJO5O67IOjZDr3VxQ492zGnih0F8-LP8e4Rv_UvBW-OBVREuvaUdLaegqXBJ7KTHqL_L_3ZP2g7-uCtGa_ohvI2HlIo6mvUWWjQX-Z7mM8BsVxCg638BRJ5sHA</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Silver, Adam C</creator><creator>Arjona, Alvaro</creator><creator>Hughes, Michael E</creator><creator>Nitabach, Michael N</creator><creator>Fikrig, Erol</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120301</creationdate><title>Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells</title><author>Silver, Adam C ; Arjona, Alvaro ; Hughes, Michael E ; Nitabach, Michael N ; Fikrig, Erol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-e0e0850afc24369fb5f3337d29f7f7866b7293feda80ccaa9ab246714a3f3e203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>ARNTL Transcription Factors - genetics</topic><topic>ARNTL Transcription Factors - metabolism</topic><topic>B cells</topic><topic>B-Lymphocytes - metabolism</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - genetics</topic><topic>Circadian Rhythm Signaling Peptides and Proteins - genetics</topic><topic>CLOCK Proteins - genetics</topic><topic>CLOCK Proteins - metabolism</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Gene Expression</topic><topic>Macrophages</topic><topic>Macrophages - metabolism</topic><topic>Mice</topic><topic>Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics</topic><topic>Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism</topic><topic>Period Circadian Proteins - genetics</topic><topic>Period Circadian Proteins - metabolism</topic><topic>Photoperiod</topic><topic>Psychiatry</topic><topic>Spleen - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silver, Adam C</creatorcontrib><creatorcontrib>Arjona, Alvaro</creatorcontrib><creatorcontrib>Hughes, Michael E</creatorcontrib><creatorcontrib>Nitabach, Michael N</creatorcontrib><creatorcontrib>Fikrig, Erol</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain, behavior, and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silver, Adam C</au><au>Arjona, Alvaro</au><au>Hughes, Michael E</au><au>Nitabach, Michael N</au><au>Fikrig, Erol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells</atitle><jtitle>Brain, behavior, and immunity</jtitle><addtitle>Brain Behav Immun</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>26</volume><issue>3</issue><spage>407</spage><epage>413</epage><pages>407-413</pages><issn>0889-1591</issn><eissn>1090-2139</eissn><abstract>► Mouse splenic macrophages, dendritic cells, and B cells possess functional circadian molecular clocks.
In mammals, circadian and daily rhythms influence nearly all aspects of physiology, ranging from behavior to gene expression. Functional molecular clocks have been described in the murine spleen and splenic NK cells. The aim of our study was to investigate the existence of molecular clock mechanisms in other immune cells. Therefore, we measured the circadian changes in gene expression of clock genes (Per1, Per2, Bmal1, and Clock) and clock-controlled transcription factors (Rev-erbα and Dbp) in splenic enriched macrophages, dendritic cells, and B cells in both mice entrained to a light–dark cycle and under constant environmental conditions. Our study reveals the existence of functional molecular clock mechanisms in splenic macrophages, dendritic cells, and B cells.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>22019350</pmid><doi>10.1016/j.bbi.2011.10.001</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Animals ARNTL Transcription Factors - genetics ARNTL Transcription Factors - metabolism B cells B-Lymphocytes - metabolism Circadian rhythm Circadian Rhythm - genetics Circadian Rhythm Signaling Peptides and Proteins - genetics CLOCK Proteins - genetics CLOCK Proteins - metabolism Dendritic cells Dendritic Cells - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Macrophages Macrophages - metabolism Mice Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism Period Circadian Proteins - genetics Period Circadian Proteins - metabolism Photoperiod Psychiatry Spleen - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| title | Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells |
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