Autoantibodies against 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase in patients with statin‐associated autoimmune myopathy

Objective In addition to inducing a self‐limited myopathy, statin use is associated with an immune‐mediated necrotizing myopathy (IMNM), with autoantibodies that recognize ∼200‐kd and ∼100‐kd autoantigens. The purpose of this study was to identify these molecules to help clarify the disease mechanis...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2011-03, Vol.63 (3), p.713-721
Hauptverfasser:	Mammen, Andrew L., Chung, Tae, Christopher‐Stine, Lisa, Rosen, Paul, Rosen, Antony, Doering, Kimberly R., Casciola‐Rosen, Livia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Aged Aged, 80 and over Autoantibodies - blood Autoantibodies - immunology Autoantigens - immunology Autoimmune Diseases - chemically induced Autoimmune Diseases - epidemiology Autoimmune Diseases - immunology Biological and medical sciences Cell adhesion & migration Child, Preschool Diseases of striated muscles. Neuromuscular diseases Diseases of the osteoarticular system Enzyme-Linked Immunosorbent Assay - methods Female Genes HeLa Cells Humans Hydroxymethylglutaryl CoA Reductases - chemistry Hydroxymethylglutaryl CoA Reductases - immunology Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Male Medical sciences Middle Aged Muscle Fibers, Skeletal - immunology Muscle Fibers, Skeletal - pathology Myositis - chemically induced Myositis - epidemiology Myositis - immunology Necrosis Neurology Protein Structure, Tertiary Regeneration - immunology Seroepidemiologic Studies Statins Young Adult
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