Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure
The most common form of neurologic injury in sickle cell anemia (SCA) is silent cerebral infarction (SCI). In the Silent Cerebral Infarct Multi-Center Clinical Trial, we sought to identify risk factors associated with SCI. In this cross-sectional study, we evaluated the clinical history and baseline...
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| Veröffentlicht in: | Blood 2012-04, Vol.119 (16), p.3684-3690 |
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| creator | DeBaun, Michael R. Sarnaik, Sharada A. Rodeghier, Mark J. Minniti, Caterina P. Howard, Thomas H. Iyer, Rathi V. Inusa, Baba Telfer, Paul T. Kirby-Allen, Melanie Quinn, Charles T. Bernaudin, Françoise Airewele, Gladstone Woods, Gerald M. Panepinto, Julie Ann Fuh, Beng Kwiatkowski, Janet K. King, Allison A. Rhodes, Melissa M. Thompson, Alexis A. Heiny, Mark E. Redding-Lallinger, Rupa C. Kirkham, Fenella J. Sabio, Hernan Gonzalez, Corina E. Saccente, Suzanne L. Kalinyak, Karen A. Strouse, John J. Fixler, Jason M. Gordon, Mae O. Miller, J. Phillip Noetzel, Michael J. Ichord, Rebecca N. Casella, James F. |
| description | The most common form of neurologic injury in sickle cell anemia (SCA) is silent cerebral infarction (SCI). In the Silent Cerebral Infarct Multi-Center Clinical Trial, we sought to identify risk factors associated with SCI. In this cross-sectional study, we evaluated the clinical history and baseline laboratory values and performed magnetic resonance imaging of the brain in participants with SCA (HbSS or HbSβ° thalassemia) between the ages of 5 and 15 years with no history of overt stroke or seizures. Neuroradiology and neurology committees adjudicated the presence of SCI. SCIs were diagnosed in 30.8% (251 of 814) participants who completed all evaluations and had valid data on all prespecified demographic and clinical covariates. The mean age of the participants was 9.1 years, with 413 males (50.7%). In a multivariable logistic regression analysis, lower baseline hemoglobin concentration (P < .001), higher baseline systolic blood pressure (P = .018), and male sex (P = .030) were statistically significantly associated with an increased risk of an SCI. Hemoglobin concentration and systolic blood pressure are risk factors for SCI in children with SCA and may be therapeutic targets for decreasing the risk of SCI. This study is registered at www.clinicaltrials.gov as #NCT00072761. |
| doi_str_mv | 10.1182/blood-2011-05-349621 |
| format | Article |
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Phillip ; Noetzel, Michael J. ; Ichord, Rebecca N. ; Casella, James F.</creator><creatorcontrib>DeBaun, Michael R. ; Sarnaik, Sharada A. ; Rodeghier, Mark J. ; Minniti, Caterina P. ; Howard, Thomas H. ; Iyer, Rathi V. ; Inusa, Baba ; Telfer, Paul T. ; Kirby-Allen, Melanie ; Quinn, Charles T. ; Bernaudin, Françoise ; Airewele, Gladstone ; Woods, Gerald M. ; Panepinto, Julie Ann ; Fuh, Beng ; Kwiatkowski, Janet K. ; King, Allison A. ; Rhodes, Melissa M. ; Thompson, Alexis A. ; Heiny, Mark E. ; Redding-Lallinger, Rupa C. ; Kirkham, Fenella J. ; Sabio, Hernan ; Gonzalez, Corina E. ; Saccente, Suzanne L. ; Kalinyak, Karen A. ; Strouse, John J. ; Fixler, Jason M. ; Gordon, Mae O. ; Miller, J. Phillip ; Noetzel, Michael J. ; Ichord, Rebecca N. ; Casella, James F.</creatorcontrib><description>The most common form of neurologic injury in sickle cell anemia (SCA) is silent cerebral infarction (SCI). In the Silent Cerebral Infarct Multi-Center Clinical Trial, we sought to identify risk factors associated with SCI. In this cross-sectional study, we evaluated the clinical history and baseline laboratory values and performed magnetic resonance imaging of the brain in participants with SCA (HbSS or HbSβ° thalassemia) between the ages of 5 and 15 years with no history of overt stroke or seizures. Neuroradiology and neurology committees adjudicated the presence of SCI. SCIs were diagnosed in 30.8% (251 of 814) participants who completed all evaluations and had valid data on all prespecified demographic and clinical covariates. The mean age of the participants was 9.1 years, with 413 males (50.7%). In a multivariable logistic regression analysis, lower baseline hemoglobin concentration (P < .001), higher baseline systolic blood pressure (P = .018), and male sex (P = .030) were statistically significantly associated with an increased risk of an SCI. Hemoglobin concentration and systolic blood pressure are risk factors for SCI in children with SCA and may be therapeutic targets for decreasing the risk of SCI. This study is registered at www.clinicaltrials.gov as #NCT00072761.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2011-05-349621</identifier><identifier>PMID: 22096242</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Adolescent ; Anemia, Sickle Cell - blood ; Anemia, Sickle Cell - epidemiology ; Anemia, Sickle Cell - therapy ; Anemias. Hemoglobinopathies ; Asymptomatic Diseases - epidemiology ; beta-Thalassemia - blood ; beta-Thalassemia - epidemiology ; Biological and medical sciences ; Blood Pressure ; Blood Transfusion ; Cerebral Infarction - blood ; Cerebral Infarction - epidemiology ; Cerebral Infarction - pathology ; Child ; Child, Preschool ; Clinical Trials and Observations ; Cross-Sectional Studies ; Diseases of red blood cells ; Female ; Hematologic and hematopoietic diseases ; Hemoglobin, Sickle - metabolism ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Multivariate Analysis ; Neurology ; Red Cells, Iron, and Erythropoiesis ; Risk Factors ; Sex Distribution ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Blood, 2012-04, Vol.119 (16), p.3684-3690</ispartof><rights>2012 American Society of Hematology</rights><rights>2015 INIST-CNRS</rights><rights>2012 by The American Society of Hematology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-26826eb0288667a421b65713db99c690330dc51f93fec9d12eb737858c333593</citedby><cites>FETCH-LOGICAL-c493t-26826eb0288667a421b65713db99c690330dc51f93fec9d12eb737858c333593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25802144$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22096242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DeBaun, Michael R.</creatorcontrib><creatorcontrib>Sarnaik, Sharada A.</creatorcontrib><creatorcontrib>Rodeghier, Mark J.</creatorcontrib><creatorcontrib>Minniti, Caterina P.</creatorcontrib><creatorcontrib>Howard, Thomas H.</creatorcontrib><creatorcontrib>Iyer, Rathi V.</creatorcontrib><creatorcontrib>Inusa, Baba</creatorcontrib><creatorcontrib>Telfer, Paul T.</creatorcontrib><creatorcontrib>Kirby-Allen, Melanie</creatorcontrib><creatorcontrib>Quinn, Charles T.</creatorcontrib><creatorcontrib>Bernaudin, Françoise</creatorcontrib><creatorcontrib>Airewele, Gladstone</creatorcontrib><creatorcontrib>Woods, Gerald M.</creatorcontrib><creatorcontrib>Panepinto, Julie Ann</creatorcontrib><creatorcontrib>Fuh, Beng</creatorcontrib><creatorcontrib>Kwiatkowski, Janet K.</creatorcontrib><creatorcontrib>King, Allison A.</creatorcontrib><creatorcontrib>Rhodes, Melissa M.</creatorcontrib><creatorcontrib>Thompson, Alexis A.</creatorcontrib><creatorcontrib>Heiny, Mark E.</creatorcontrib><creatorcontrib>Redding-Lallinger, Rupa C.</creatorcontrib><creatorcontrib>Kirkham, Fenella J.</creatorcontrib><creatorcontrib>Sabio, Hernan</creatorcontrib><creatorcontrib>Gonzalez, Corina E.</creatorcontrib><creatorcontrib>Saccente, Suzanne L.</creatorcontrib><creatorcontrib>Kalinyak, Karen A.</creatorcontrib><creatorcontrib>Strouse, John J.</creatorcontrib><creatorcontrib>Fixler, Jason M.</creatorcontrib><creatorcontrib>Gordon, Mae O.</creatorcontrib><creatorcontrib>Miller, J. Phillip</creatorcontrib><creatorcontrib>Noetzel, Michael J.</creatorcontrib><creatorcontrib>Ichord, Rebecca N.</creatorcontrib><creatorcontrib>Casella, James F.</creatorcontrib><title>Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure</title><title>Blood</title><addtitle>Blood</addtitle><description>The most common form of neurologic injury in sickle cell anemia (SCA) is silent cerebral infarction (SCI). In the Silent Cerebral Infarct Multi-Center Clinical Trial, we sought to identify risk factors associated with SCI. In this cross-sectional study, we evaluated the clinical history and baseline laboratory values and performed magnetic resonance imaging of the brain in participants with SCA (HbSS or HbSβ° thalassemia) between the ages of 5 and 15 years with no history of overt stroke or seizures. Neuroradiology and neurology committees adjudicated the presence of SCI. SCIs were diagnosed in 30.8% (251 of 814) participants who completed all evaluations and had valid data on all prespecified demographic and clinical covariates. The mean age of the participants was 9.1 years, with 413 males (50.7%). In a multivariable logistic regression analysis, lower baseline hemoglobin concentration (P < .001), higher baseline systolic blood pressure (P = .018), and male sex (P = .030) were statistically significantly associated with an increased risk of an SCI. Hemoglobin concentration and systolic blood pressure are risk factors for SCI in children with SCA and may be therapeutic targets for decreasing the risk of SCI. This study is registered at www.clinicaltrials.gov as #NCT00072761.</description><subject>Adolescent</subject><subject>Anemia, Sickle Cell - blood</subject><subject>Anemia, Sickle Cell - epidemiology</subject><subject>Anemia, Sickle Cell - therapy</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Asymptomatic Diseases - epidemiology</subject><subject>beta-Thalassemia - blood</subject><subject>beta-Thalassemia - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Blood Transfusion</subject><subject>Cerebral Infarction - blood</subject><subject>Cerebral Infarction - epidemiology</subject><subject>Cerebral Infarction - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Trials and Observations</subject><subject>Cross-Sectional Studies</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobin, Sickle - metabolism</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Neurology</subject><subject>Red Cells, Iron, and Erythropoiesis</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UctuFDEQtBCILIE_QMgXJA4ZaNvjGQ-HSFHES4rEJXfL4-nZNfGOF_fsQr6DH8abXRK4cLKlquruqmLspYC3Qhj5ro8pDZUEISrQlaq7RopHbCG0NBWAhMdsAQBNVXetOGHPiL4BiFpJ_ZSdSAmFXssF-3VBlHxwMw48B7rho_NzysTHlDmFiNPMPWbss4s8TKPLfqbyKZi_iViwGLmbcB3cex7TD947whgm5Ctcp2VMfZjOOOHPs8IqKzC6OewKGpYrTrc0pxg8v_PCNxmJthmfsyeji4Qvju8pu_744fryc3X19dOXy4urytedmivZGNlgD9KYpmldLUXf6Faooe8633SgFAxei7FTI_puEBL7VrVGG6-U0p06ZeeHsZttv8bBF6vFpN3ksHb51iYX7L_IFFZ2mXZ2L1dtWwa8OQ7I6fsWabbrQPtASh5pS1YAGCNNo3Wh1geqz4ko43i_RoDd12nvIrD7Oi1oe6izyF79feK96E9_hfD6SHDkXRyzm3ygB542IEVdP3jFkucuYLbkA04eh5DRz3ZI4f-X_AZybcEh</recordid><startdate>20120419</startdate><enddate>20120419</enddate><creator>DeBaun, Michael R.</creator><creator>Sarnaik, Sharada A.</creator><creator>Rodeghier, Mark J.</creator><creator>Minniti, Caterina P.</creator><creator>Howard, Thomas H.</creator><creator>Iyer, Rathi V.</creator><creator>Inusa, Baba</creator><creator>Telfer, Paul T.</creator><creator>Kirby-Allen, Melanie</creator><creator>Quinn, Charles T.</creator><creator>Bernaudin, Françoise</creator><creator>Airewele, Gladstone</creator><creator>Woods, Gerald M.</creator><creator>Panepinto, Julie Ann</creator><creator>Fuh, Beng</creator><creator>Kwiatkowski, Janet K.</creator><creator>King, Allison A.</creator><creator>Rhodes, Melissa M.</creator><creator>Thompson, Alexis A.</creator><creator>Heiny, Mark E.</creator><creator>Redding-Lallinger, Rupa C.</creator><creator>Kirkham, Fenella J.</creator><creator>Sabio, Hernan</creator><creator>Gonzalez, Corina E.</creator><creator>Saccente, Suzanne L.</creator><creator>Kalinyak, Karen A.</creator><creator>Strouse, John J.</creator><creator>Fixler, Jason M.</creator><creator>Gordon, Mae O.</creator><creator>Miller, J. Phillip</creator><creator>Noetzel, Michael J.</creator><creator>Ichord, Rebecca N.</creator><creator>Casella, James F.</creator><general>Elsevier Inc</general><general>Americain Society of Hematology</general><general>American Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120419</creationdate><title>Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure</title><author>DeBaun, Michael R. ; Sarnaik, Sharada A. ; Rodeghier, Mark J. ; Minniti, Caterina P. ; Howard, Thomas H. ; Iyer, Rathi V. ; Inusa, Baba ; Telfer, Paul T. ; Kirby-Allen, Melanie ; Quinn, Charles T. ; Bernaudin, Françoise ; Airewele, Gladstone ; Woods, Gerald M. ; Panepinto, Julie Ann ; Fuh, Beng ; Kwiatkowski, Janet K. ; King, Allison A. ; Rhodes, Melissa M. ; Thompson, Alexis A. ; Heiny, Mark E. ; Redding-Lallinger, Rupa C. ; Kirkham, Fenella J. ; Sabio, Hernan ; Gonzalez, Corina E. ; Saccente, Suzanne L. ; Kalinyak, Karen A. ; Strouse, John J. ; Fixler, Jason M. ; Gordon, Mae O. ; Miller, J. 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Phillip</creatorcontrib><creatorcontrib>Noetzel, Michael J.</creatorcontrib><creatorcontrib>Ichord, Rebecca N.</creatorcontrib><creatorcontrib>Casella, James F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DeBaun, Michael R.</au><au>Sarnaik, Sharada A.</au><au>Rodeghier, Mark J.</au><au>Minniti, Caterina P.</au><au>Howard, Thomas H.</au><au>Iyer, Rathi V.</au><au>Inusa, Baba</au><au>Telfer, Paul T.</au><au>Kirby-Allen, Melanie</au><au>Quinn, Charles T.</au><au>Bernaudin, Françoise</au><au>Airewele, Gladstone</au><au>Woods, Gerald M.</au><au>Panepinto, Julie Ann</au><au>Fuh, Beng</au><au>Kwiatkowski, Janet K.</au><au>King, Allison A.</au><au>Rhodes, Melissa M.</au><au>Thompson, Alexis A.</au><au>Heiny, Mark E.</au><au>Redding-Lallinger, Rupa C.</au><au>Kirkham, Fenella J.</au><au>Sabio, Hernan</au><au>Gonzalez, Corina E.</au><au>Saccente, Suzanne L.</au><au>Kalinyak, Karen A.</au><au>Strouse, John J.</au><au>Fixler, Jason M.</au><au>Gordon, Mae O.</au><au>Miller, J. Phillip</au><au>Noetzel, Michael J.</au><au>Ichord, Rebecca N.</au><au>Casella, James F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2012-04-19</date><risdate>2012</risdate><volume>119</volume><issue>16</issue><spage>3684</spage><epage>3690</epage><pages>3684-3690</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>The most common form of neurologic injury in sickle cell anemia (SCA) is silent cerebral infarction (SCI). In the Silent Cerebral Infarct Multi-Center Clinical Trial, we sought to identify risk factors associated with SCI. In this cross-sectional study, we evaluated the clinical history and baseline laboratory values and performed magnetic resonance imaging of the brain in participants with SCA (HbSS or HbSβ° thalassemia) between the ages of 5 and 15 years with no history of overt stroke or seizures. Neuroradiology and neurology committees adjudicated the presence of SCI. SCIs were diagnosed in 30.8% (251 of 814) participants who completed all evaluations and had valid data on all prespecified demographic and clinical covariates. The mean age of the participants was 9.1 years, with 413 males (50.7%). In a multivariable logistic regression analysis, lower baseline hemoglobin concentration (P < .001), higher baseline systolic blood pressure (P = .018), and male sex (P = .030) were statistically significantly associated with an increased risk of an SCI. Hemoglobin concentration and systolic blood pressure are risk factors for SCI in children with SCA and may be therapeutic targets for decreasing the risk of SCI. This study is registered at www.clinicaltrials.gov as #NCT00072761.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>22096242</pmid><doi>10.1182/blood-2011-05-349621</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-4971 |
| ispartof | Blood, 2012-04, Vol.119 (16), p.3684-3690 |
| issn | 0006-4971 1528-0020 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3335377 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Anemia, Sickle Cell - blood Anemia, Sickle Cell - epidemiology Anemia, Sickle Cell - therapy Anemias. Hemoglobinopathies Asymptomatic Diseases - epidemiology beta-Thalassemia - blood beta-Thalassemia - epidemiology Biological and medical sciences Blood Pressure Blood Transfusion Cerebral Infarction - blood Cerebral Infarction - epidemiology Cerebral Infarction - pathology Child Child, Preschool Clinical Trials and Observations Cross-Sectional Studies Diseases of red blood cells Female Hematologic and hematopoietic diseases Hemoglobin, Sickle - metabolism Humans Magnetic Resonance Imaging Male Medical sciences Multivariate Analysis Neurology Red Cells, Iron, and Erythropoiesis Risk Factors Sex Distribution Vascular diseases and vascular malformations of the nervous system |
| title | Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T19%3A56%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Associated%20risk%20factors%20for%20silent%20cerebral%20infarcts%20in%20sickle%20cell%20anemia:%20low%20baseline%20hemoglobin,%20sex,%20and%20relative%20high%20systolic%20blood%20pressure&rft.jtitle=Blood&rft.au=DeBaun,%20Michael%20R.&rft.date=2012-04-19&rft.volume=119&rft.issue=16&rft.spage=3684&rft.epage=3690&rft.pages=3684-3690&rft.issn=0006-4971&rft.eissn=1528-0020&rft_id=info:doi/10.1182/blood-2011-05-349621&rft_dat=%3Cproquest_pubme%3E1008828655%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1008828655&rft_id=info:pmid/22096242&rft_els_id=S0006497120479844&rfr_iscdi=true |