INT6/EIF3E Interacts with ATM and Is Required for Proper Execution of the DNA Damage Response in Human Cells

Altered expression of the INT6 gene, encoding the e subunit of the translational initiation factor eIF3, occurs in human breast cancers, but how INT6 relates to carcinogenesis remains unestablished. Here, we show that INT6 is involved in the DNA damage response. INT6 was required for cell survival f...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2012-04, Vol.72 (8), p.2006-2016
Hauptverfasser:	MORRIS, Christelle, TOMIMATSU, Nozomi, RICHARD, Derek J, CLUET, David, BURMA, Sandeep, KUM KHANNA, Kum, JALINOT, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Ataxia telangiectasia mutated protein Ataxia Telangiectasia Mutated Proteins Biological and medical sciences BRCA1 protein BRCA1 Protein - metabolism Breast cancer Cancer Carcinogenesis Cell Cycle Checkpoints Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Survival Cell Transformation, Neoplastic - metabolism CHK1 protein DNA damage DNA Damage - physiology DNA repair DNA-Binding Proteins - metabolism Drugs Eukaryotic Initiation Factor-3 - metabolism Fluorescent Antibody Technique Gene Knockdown Techniques Humans Immunoblotting Immunoprecipitation Initiation factors INT6 gene Life Sciences Medical sciences Microscopy, Confocal Pharmacology. Drug treatments Phosphorylation Protein-Serine-Threonine Kinases - metabolism RNA RNA-mediated interference Translation Tumor Suppressor Proteins - metabolism Tumors Ubiquitin
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