Novel peptide for attenuation of hypoxia-induced pulmonary hypertension via modulation of nitric oxide release and phosphodiesterase -5 activity

► Peptide therapy attenuates hypoxia-induced pulmonary artery hypertension and vascular remodeling. ► The effect was found to be mediated by increased NO-release and inhibition of cGMP-specific PDE-5. ► Dual action of the peptide that enhance NO release and diminished PDE-5 activity resulted in sust...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2012-05, Vol.35 (1), p.78-85
Hauptverfasser:	Hu, Hanbo, Zharikov, Sergey, Patel, Jawaharlal M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amino acids Animals Blood Pressure - drug effects Catalytic activity Cell Hypoxia Cells, Cultured Cyclic GMP Cyclic GMP - metabolism Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism Elevated endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism endothelial nitric oxide synthase guanosine hypertension Hypertension, Pulmonary - drug therapy hypertrophy Hypertrophy, Right Ventricular - prevention & control Hypoxia In Vitro Techniques Inhibition Inhibitors Lung - drug effects Lung - metabolism lungs Male Modulation monitoring Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - pharmacology Nitric Oxide Synthase Type III - therapeutic use oxygen Peptide Fragments - pharmacology Peptide Fragments - therapeutic use Peptides Phosphodiesterase 5 Inhibitors - pharmacology Phosphodiesterase 5 Inhibitors - therapeutic use Phosphodiesterase-5 polycyclic aromatic hydrocarbons Protein Binding protein synthesis pulmonary artery Pulmonary Artery - drug effects Pulmonary Artery - pathology Pulmonary artery pressure Pulmonary circulation Pulmonary hypertension Rats Rats, Sprague-Dawley Remodeling Swine Synthetic peptide Telemetry therapeutics vasoconstriction vasodilation Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use
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