Sequence dependent modulating effect of camptothecin on the DNA-cleaving activity of the calf thymus type I topoisomerase
High-resolution mapping of topol cleavages in the regions of human DNA including the oncogene c-Ha-ras and p53, has revealed three kinds of topol cleavage sites: cleavage sites not affected by camptothecin; cleavage sites reinforced only in the presence of camptothecin, and cleavage sites which weak...
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| Veröffentlicht in: | Nucleic acids research 1990-02, Vol.18 (3), p.637-645 |
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| container_title | Nucleic acids research |
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| creator | GROMOVA, I. I BUCHMAN, V. L ABAGYAN, R. A ULYANOV, A. V BRONSTEIN, I. B |
| description | High-resolution mapping of topol cleavages in the regions of human DNA including the oncogene c-Ha-ras and p53, has revealed three kinds of topol cleavage sites: cleavage sites not affected by camptothecin; cleavage sites reinforced only in the presence of camptothecin, and cleavage sites which weaken in the presence of camptothecin. Statistical analysis of sequences revealed certain nucleotide or dinucleotide preferences for three groups studied. The preferences in camptothecin-reduced sites predominate upstream from the cleavage point, whereas in camptothecin-induced sites the situation is reversed. The influence of camptothecin on cleavage sites induced by two molecular forms of topol has been also studied. |
| doi_str_mv | 10.1093/nar/18.3.637 |
| format | Article |
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I</creatorcontrib><creatorcontrib>BUCHMAN, V. L</creatorcontrib><creatorcontrib>ABAGYAN, R. A</creatorcontrib><creatorcontrib>ULYANOV, A. V</creatorcontrib><creatorcontrib>BRONSTEIN, I. B</creatorcontrib><title>Sequence dependent modulating effect of camptothecin on the DNA-cleaving activity of the calf thymus type I topoisomerase</title><title>Nucleic acids research</title><addtitle>Nucleic Acids Res</addtitle><description>High-resolution mapping of topol cleavages in the regions of human DNA including the oncogene c-Ha-ras and p53, has revealed three kinds of topol cleavage sites: cleavage sites not affected by camptothecin; cleavage sites reinforced only in the presence of camptothecin, and cleavage sites which weaken in the presence of camptothecin. Statistical analysis of sequences revealed certain nucleotide or dinucleotide preferences for three groups studied. The preferences in camptothecin-reduced sites predominate upstream from the cleavage point, whereas in camptothecin-induced sites the situation is reversed. The influence of camptothecin on cleavage sites induced by two molecular forms of topol has been also studied.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Camptothecin - pharmacology</subject><subject>Cattle</subject><subject>DNA - metabolism</subject><subject>DNA Topoisomerases, Type I - metabolism</subject><subject>Dna, deoxyribonucleoproteins</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Molecular Sequence Data</subject><subject>Nucleic acids</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins p21(ras)</subject><subject>Restriction Mapping</subject><subject>Substrate Specificity</subject><subject>Thymus Gland - enzymology</subject><issn>0305-1048</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EKtvCjSuSD4gT2drx94FDVShUquAAnC3HmbRBiR1iZ6X89zjqagWnnmak95vRvHkIvaFkT4lhl8HNl1Tv2V4y9QztKJN1xY2sn6MdYURUlHD9Ep2n9JsQyqngZ-ispkJwonZo_QF_FggecAsThBZCxmNsl8HlPtxj6DrwGccOezdOOeYH8H3AMeDS4U_frio_gDtsqPO5P_R53eBN9G7YmnVcEs7rBPgW5zjFPsURZpfgFXrRuSHB62O9QL9uPv-8_lrdff9ye311V3mmuaqk0JK1qpFdrZUyXBpBtaFCsq41UnjoFBNQK6O0JgVrOqY9bSij4KHxnF2gj497p6UZofXF4ewGO8396ObVRtfb_5XQP9j7eLCMMa5YmX9_nJ9jeVXKduyTh2FwAeKSrCpX6NqoJ0Fqyj5C5NOgUNxwQgv44RH0c0xphu50NSV2y96W7C3VltmSfcHf_uv0BB_DLvq7o-7Sls7sgu_TCZOmPFYr9hc4Tbjg</recordid><startdate>19900211</startdate><enddate>19900211</enddate><creator>GROMOVA, I. 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Psychology</topic><topic>Humans</topic><topic>Molecular Sequence Data</topic><topic>Nucleic acids</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins p21(ras)</topic><topic>Restriction Mapping</topic><topic>Substrate Specificity</topic><topic>Thymus Gland - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GROMOVA, I. I</creatorcontrib><creatorcontrib>BUCHMAN, V. L</creatorcontrib><creatorcontrib>ABAGYAN, R. A</creatorcontrib><creatorcontrib>ULYANOV, A. V</creatorcontrib><creatorcontrib>BRONSTEIN, I. 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B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequence dependent modulating effect of camptothecin on the DNA-cleaving activity of the calf thymus type I topoisomerase</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Res</addtitle><date>1990-02-11</date><risdate>1990</risdate><volume>18</volume><issue>3</issue><spage>637</spage><epage>645</epage><pages>637-645</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><coden>NARHAD</coden><abstract>High-resolution mapping of topol cleavages in the regions of human DNA including the oncogene c-Ha-ras and p53, has revealed three kinds of topol cleavage sites: cleavage sites not affected by camptothecin; cleavage sites reinforced only in the presence of camptothecin, and cleavage sites which weaken in the presence of camptothecin. Statistical analysis of sequences revealed certain nucleotide or dinucleotide preferences for three groups studied. 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| ispartof | Nucleic acids research, 1990-02, Vol.18 (3), p.637-645 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; PubMed Central |
| subjects | Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences Camptothecin - pharmacology Cattle DNA - metabolism DNA Topoisomerases, Type I - metabolism Dna, deoxyribonucleoproteins Fundamental and applied biological sciences. Psychology Humans Molecular Sequence Data Nucleic acids Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) Restriction Mapping Substrate Specificity Thymus Gland - enzymology |
| title | Sequence dependent modulating effect of camptothecin on the DNA-cleaving activity of the calf thymus type I topoisomerase |
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