CLIC4 is a tumor suppressor for cutaneous squamous cell cancer

Chloride intracellular channel (CLIC) 4 is a member of a redox-regulated, metamorphic multifunctional protein family, first characterized as intracellular chloride channels. Current knowledge indicates that CLICs participate in signaling, cytoskeleton integrity and differentiation functions of multi...

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Veröffentlicht in:	Carcinogenesis (New York) 2012-05, Vol.33 (5), p.986-995
Hauptverfasser:	Suh, K Stephen, Malik, Mariam, Shukla, Anjali, Ryscavage, Andrew, Wright, Lisa, Jividen, Kasey, Crutchley, John M, Dumont, Rebecca A, Fernandez-Salas, Ester, Webster, Joshua D, Simpson, R Mark, Yuspa, Stuart H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Benign Biology, Genetics and Epigenetics Cancer Carcinogenesis Carcinoma Cell Line, Tumor Cell Nucleus - genetics Cell Nucleus - metabolism Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Chloride channels Chloride Channels - biosynthesis Chloride Channels - genetics Chloride Channels - metabolism Cytoskeleton Dephosphorylation Differentiation Epidermis Fibroblasts - metabolism Humans Keratinocytes Keratinocytes - metabolism Male Mice Mice, Inbred BALB C Mice, Inbred SENCAR Mitochondrial Proteins - biosynthesis Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Neoplasms, Squamous Cell - genetics Neoplasms, Squamous Cell - metabolism Nuclear transport Oxidation-Reduction Papilloma Papilloma - genetics Papilloma - metabolism protein families Protein Transport Redox properties Signal Transduction Skin Skin Neoplasms - genetics Skin Neoplasms - metabolism Squamous cells Transcription Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming growth factor- beta Tumor cell lines Tumor cells Tumor suppressor genes Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors
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