Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

Recent advances in high-throughput cDNA sequencing (RNA-seq) can reveal new genes and splice variants and quantify expression genome-wide in a single assay. The volume and complexity of data from RNA-seq experiments necessitate scalable, fast and mathematically principled analysis software. TopHat a...

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Veröffentlicht in:	Nature protocols 2012-03, Vol.7 (3), p.562-578
Hauptverfasser:	Trapnell, Cole, Roberts, Adam, Goff, Loyal, Pertea, Geo, Kim, Daehwan, Kelley, David R, Pimentel, Harold, Salzberg, Steven L, Rinn, John L, Pachter, Lior
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114/794 631/1647/2017 631/1647/514/1949 631/1647/514/2254 Alternative splicing Analysis Analytical Chemistry Bioinformatics Biological Techniques Biologists Biology Biomedical and Life Sciences Computational Biology/Bioinformatics Computer programs Computer science Computers Data processing DNA, Complementary - genetics Experiments Gene expression Gene Expression Profiling - methods Genes Genetic Association Studies - methods Genomes Genomics - methods Informatics Life Sciences Microarrays Nucleotide sequence Open source software Organic Chemistry Protocol Public software RNA sequencing Sequence Analysis, DNA - methods Software Software utilities Transcription
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