Drug Interactions of Clinical Importance among the Opioids, Methadone and Buprenorphine, and Other Frequently Prescribed Medications: A Review
Drug interactions are a leading cause of morbidity and mortality. Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co‐occurring medical and mental illnesses that require medication treatment. The...
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| Veröffentlicht in: | The American journal on addictions 2010-01, Vol.19 (1), p.4-16 |
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| container_title | The American journal on addictions |
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| creator | McCance-Katz, Elinore F. Sullivan, Lynn E. Nallani, Srikanth |
| description | Drug interactions are a leading cause of morbidity and mortality. Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co‐occurring medical and mental illnesses that require medication treatment. The abuse of illicit substances is also common in opioid‐addicted individuals. These clinical realities place patients being treated with methadone and buprenorphine at risk for potentially toxic drug interactions. A substantial literature has accumulated on drug interactions between either methadone or buprenorphine with other medications when ingested concomitantly by humans. This review summarizes current literature in this area. (Am J Addict 2009;19:4–16) |
| doi_str_mv | 10.1111/j.1521-0391.2009.00005.x |
| format | Article |
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Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co‐occurring medical and mental illnesses that require medication treatment. The abuse of illicit substances is also common in opioid‐addicted individuals. These clinical realities place patients being treated with methadone and buprenorphine at risk for potentially toxic drug interactions. A substantial literature has accumulated on drug interactions between either methadone or buprenorphine with other medications when ingested concomitantly by humans. This review summarizes current literature in this area. 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| identifier | ISSN: 1055-0496 |
| ispartof | The American journal on addictions, 2010-01, Vol.19 (1), p.4-16 |
| issn | 1055-0496 1521-0391 |
| language | eng |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Addicts Buprenorphine Buprenorphine - adverse effects Buprenorphine - pharmacokinetics Cytochrome P-450 CYP2D6 Inhibitors Drug Interactions Humans Illicit Drugs - adverse effects Methadone Methadone - adverse effects Methadone - pharmacokinetics Methadone - pharmacology Morbidity-Mortality Opioid-Related Disorders - drug therapy Opioids Prescribed Prescription Drugs - adverse effects Substance-Related Disorders - complications Substance-Related Disorders - drug therapy |
| title | Drug Interactions of Clinical Importance among the Opioids, Methadone and Buprenorphine, and Other Frequently Prescribed Medications: A Review |
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