Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants

ERK5 MAP kinase is highly expressed in the developing nervous system and has been implicated in promoting the survival of immature neurons in culture. However, its role in the development and function of the mammalian nervous system has not been established in vivo. Here, we report that conditional...

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Veröffentlicht in:	The Journal of neuroscience 2012-03, Vol.32 (12), p.4118-4132
Hauptverfasser:	Zou, Junhui, Pan, Yung-Wei, Wang, Zhenshan, Chang, Shih-Yu, Wang, Wenbin, Wang, Xin, Tournier, Cathy, Storm, Daniel R, Xia, Zhengui
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Analysis of Variance Animals Animals, Newborn Apoptosis - genetics Bromodeoxyuridine - metabolism Cell Movement Disease Models, Animal Electrooculography - methods Embryo, Mammalian GABAergic Neurons - physiology Gene Expression Regulation, Developmental - genetics Glutamate Decarboxylase - metabolism In Situ Nick-End Labeling Lateral Ventricles - embryology Lateral Ventricles - growth & development Lateral Ventricles - pathology Mice Mice, Transgenic Mitogen-Activated Protein Kinase 7 - deficiency Mitogen-Activated Protein Kinase 7 - genetics Neural Cell Adhesion Molecule L1 - metabolism Neural Stem Cells - physiology Neurogenesis - genetics Odorants Olfactory Bulb - embryology Olfactory Bulb - growth & development Olfactory Bulb - pathology Perceptual Disorders - genetics Perceptual Disorders - pathology Phosphopyruvate Hydratase - metabolism Sialic Acids - metabolism Signal Transduction Smell - genetics SOXB1 Transcription Factors - metabolism
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