Deficiency of lymphotoxin-α does not exacerbate high-fat diet-induced obesity but does enhance inflammation in mice

Lymphotoxin-α (LTα) is secreted by lymphocytes and acts through tumor necrosis factor-α receptors and the LTβ receptor. Our goals were to determine whether LT has a role in obesity and investigate whether LT contributes to the link between obesity and adipose tissue lymphocyte accumulation. LT defic...

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Veröffentlicht in:American journal of physiology: endocrinology and metabolism 2012-04, Vol.302 (8), p.E961-E971
Hauptverfasser: Pamir, Nathalie, McMillen, Timothy S, Edgel, Kimberly A, Kim, Francis, LeBoeuf, Renée C
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Sprache:eng
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