Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation

Multiciliate cells function prominently in the respiratory system, brain ependyma and female reproductive tract to produce vigorous fluid flow along epithelial surfaces. These specialized cells form during development when epithelial progenitors undergo an unusual form of ciliogenesis, in which they...

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Veröffentlicht in:	Nature cell biology 2012-02, Vol.14 (2), p.140-147
Hauptverfasser:	Stubbs, J. L., Vladar, E. K., Axelrod, J. D., Kintner, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/2432 631/208/199 631/80/128/1965 Amino Acid Sequence Animals Animals, Genetically Modified Biomedical and Life Sciences Cancer Research Cell Biology Cell Differentiation Cell Nucleus - metabolism Cells Centrioles - physiology Cilia - physiology Cilia and ciliary motion Developmental Biology DNA binding proteins Embryo, Nonmammalian - cytology Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Embryos Female Females Gene expression Gene Expression Regulation, Developmental Genetic aspects Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HEK293 Cells Humans In Situ Hybridization Kidney - cytology Kidney - embryology Kidney - metabolism Kidneys Life Sciences Male Mice Microscopy, Electron, Transmission Microscopy, Fluorescence Molecular Sequence Data Neurosciences Physiological aspects Proteins Respiratory system Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Amino Acid Skin Skin - cytology Skin - embryology Skin - metabolism Stem Cells Transplants & implants Xenopus Xenopus laevis - embryology Xenopus laevis - genetics Xenopus laevis - metabolism Xenopus Proteins - genetics Xenopus Proteins - metabolism Xenopus Proteins - physiology
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