Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo

The concentration of amyloid-β (Aβ) within the brain extracellular space is one determinant of whether the peptide will aggregate into toxic species that are important in Alzheimer's disease (AD) pathogenesis. Some types of synaptic activity can regulate Aβ levels. Here we demonstrate two disti...

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Veröffentlicht in:	The Journal of neuroscience 2011-08, Vol.31 (31), p.11328-11337
Hauptverfasser:	Verges, Deborah K, Restivo, Jessica L, Goebel, Whitney D, Holtzman, David M, Cirrito, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - genetics Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Analysis of Variance Animals Brain Waves - drug effects Calcium - metabolism Chelating Agents - pharmacology Dose-Response Relationship, Drug Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Electroencephalography - methods Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay - methods Excitatory Amino Acid Antagonists - pharmacology Extracellular Signal-Regulated MAP Kinases - metabolism Extracellular Space - drug effects Extracellular Space - metabolism Flavones - pharmacology Humans Mice Mice, Inbred C57BL Mice, Transgenic Mutation - genetics N-Methylaspartate - pharmacology Piperazines - pharmacology Piperidines - pharmacology Pregnanolone - pharmacology Presenilin-1 - genetics Presenilin-1 - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Serotonin - pharmacology Sodium Channel Blockers - pharmacology Synapses - drug effects Synapses - metabolism Synapses - pathology Tetrodotoxin - pharmacology
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