Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension

Hypertension, a powerful risk factor for stroke and dementia, has damaging effects on the brain and its vessels. In particular, hypertension alters vital cerebrovascular control mechanisms linking neural activity to cerebral perfusion. In experimental models of slow-developing hypertension, free rad...

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Veröffentlicht in:	The Journal of neuroscience 2012-04, Vol.32 (14), p.4878-4886
Hauptverfasser:	Capone, Carmen, Faraco, Giuseppe, Peterson, Jeffrey R, Coleman, Christal, Anrather, Josef, Milner, Teresa A, Pickel, Virginia M, Davisson, Robin L, Iadecola, Costantino
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - physiology Angiotensin II - toxicity Animals Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Gene Transfer Techniques Hypertension - chemically induced Hypertension - pathology Hypertension - physiopathology Male Mice Mice, Inbred C57BL Reactive Oxygen Species - metabolism Receptor, Angiotensin, Type 1 - agonists Receptor, Angiotensin, Type 1 - physiology Subfornical Organ - drug effects Subfornical Organ - physiopathology
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