Human telomeres replicate using chromosome-specific, rather than universal, replication programs

Telomeric and adjacent subtelomeric heterochromatin pose significant challenges to the DNA replication machinery. Little is known about how replication progresses through these regions in human cells. Using single molecule analysis of replicated DNA (SMARD), we delineate the replication programs-i.e...

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Veröffentlicht in:	The Journal of cell biology 2012-04, Vol.197 (2), p.253-266
Hauptverfasser:	Drosopoulos, William C, Kosiyatrakul, Settapong T, Yan, Zi, Calderano, Simone G, Schildkraut, Carl L
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Chromatin Chromosomes Chromosomes, Human - metabolism Deoxyribonucleic acid DNA DNA - metabolism DNA Replication - physiology Embryonic Stem Cells - metabolism HeLa Cells Heterochromatin Humans Stem cells Telomere - metabolism
Online-Zugang:	Volltext
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