Genetic Variation in NCAM1 Contributes to Left Ventricular Wall Thickness in Hypertensive Families

RATIONALE:Left ventricular (LV) mass and related phenotypes are heritable, important predictors of cardiovascular disease, particularly in hypertensive individuals. OBJECTIVE:Identify genetic predictors of echocardiographic phenotypes in hypertensive families. METHODS AND RESULTS:A multistage genome...

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Veröffentlicht in:	Circulation research 2011-02, Vol.108 (3), p.279-283
Hauptverfasser:	Arnett, Donna K, Meyers, Kristin J, Devereux, Richard B, Tiwari, Hemant K, Gu, Charles C, Vaughan, Laura K, Perry, Rodney T, Patki, Amit, Claas, Steven A, Sun, Yan V, Broeckel, Ulrich, Kardia, Sharon L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Continental Ancestry Group - ethnology African Continental Ancestry Group - genetics Aged Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system CD56 Antigen - genetics European Continental Ancestry Group - ethnology European Continental Ancestry Group - genetics Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease - genetics Genome-Wide Association Study Heart Ventricles - diagnostic imaging Heart Ventricles - pathology Humans Hypertension - ethnology Hypertension - genetics Hypertension - pathology Hypertrophy, Left Ventricular - ethnology Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - pathology Male Medical sciences Middle Aged Phenotype Polymorphism, Single Nucleotide - genetics Ultrasonography Vertebrates: cardiovascular system
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