Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

It was reported previously that isolated human islets from individuals with type 2 diabetes mellitus (T2DM) show reduced glucose-stimulated insulin release. To assess the possibility that impaired bioenergetics may contribute to this defect, glucose-stimulated respiration (Vo(2)), glucose usage and...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2012-01, Vol.302 (1), p.E87-E102
Hauptverfasser:	Doliba, Nicolai M, Qin, Wei, Najafi, Habiba, Liu, Chengyang, Buettger, Carol W, Sotiris, Johanna, Collins, Heather W, Li, Changhong, Stanley, Charles A, Wilson, David F, Grimsby, Joseph, Sarabu, Ramakanth, Naji, Ali, Matschinsky, Franz M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adult Animals Benzeneacetamides - pharmacology Calcium Signaling - drug effects Cell Respiration - drug effects Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Enzyme Activators - pharmacology Exenatide Female Glucagon-Like Peptide 1 - analogs & derivatives Glucokinase - chemistry Glucokinase - metabolism Glucose Glucose - metabolism Glycolysis - drug effects Humans Hypoglycemic Agents - pharmacology Insulin Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - metabolism Male Mice Middle Aged Oxidation Oxidative Phosphorylation - drug effects Peptides - pharmacology Rats Rodents Species Specificity Tissue Culture Techniques Venoms - pharmacology
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