DNA Demethylation-Dependent AR Recruitment and GATA Factors Drive Rhox5 Homeobox Gene Transcription in the Epididymis

Mammalian male fertility depends on the epididymis, a highly segmented organ that promotes sperm maturation and protects sperm from oxidative damage. Remarkably little is known about how gene expression is controlled in the epididymis. A candidate to regulate genes crucial for epididymal function is...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2012-04, Vol.26 (4), p.538-549
Hauptverfasser:	Bhardwaj, Anjana, Song, Hye-Won, Beildeck, Marcy, Kerkhofs, Stefanie, Castoro, Ryan, Shanker, Sreenath, De Gendt, Karel, Suzuki, Kichiya, Claessens, Frank, Pierre Issa, Jean, Orgebin-Crist, Marie-Claire, Wilkinson, Miles F
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - physiology Animals Cell Line DNA Methylation Epididymis - metabolism GATA Transcription Factors - physiology Gene Expression Regulation, Developmental Genes, Reporter Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Luciferases - biosynthesis Luciferases - genetics Male Mice Mice, Inbred C57BL Mice, Transgenic Organ Specificity Original Research Receptors, Androgen - genetics Receptors, Androgen - metabolism Response Elements Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
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