Bystander Activation of iNKT Cells Occurs During Conventional T‐Cell Alloresponses

It is well established that iNKT cells can be activated by both exogenous and a limited number of endogenous glycolipids. However, although iNKT cells have been implicated in the immune response to transplanted organs, the mechanisms by which iNKT cells are activated in this context remain unknown....

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Veröffentlicht in:	American journal of transplantation 2012-03, Vol.12 (3), p.590-599
Hauptverfasser:	Jukes, J.‐P., Wood, K. J., Jones, N. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allorecognition Animals Antigen Presentation - immunology Antigens, CD1d - immunology Apoptosis Biological and medical sciences Blotting, Western bystander activation Bystander Effect Cell Proliferation Cells, Cultured Cytokines - genetics Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Graft Rejection - immunology Graft Survival - immunology iNKT cells Interleukin-2 - immunology Interleukin-2 - metabolism Isoantigens - immunology Lymphocyte Activation - immunology Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Natural Killer T-Cells - cytology Natural Killer T-Cells - immunology Natural Killer T-Cells - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Skin Transplantation - immunology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases T-Lymphocytes - immunology transplantation Transplantation Tolerance - immunology
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