Pneumocystis elicits a STAT6-dependent, strain-specific innate immune response and airway hyperresponsiveness

It is widely held that exposure to pathogens such as fungi can be an agent of comorbidity, such as exacerbation of asthma or chronic obstructive pulmonary disease. Although many studies have examined allergic responses to fungi and their effects on pulmonary function, the possible pathologic implica...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2012-03, Vol.46 (3), p.290-298
Hauptverfasser:	Swain, Steve D, Meissner, Nicole N, Siemsen, Dan W, McInnerney, Kate, Harmsen, Allen G
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - metabolism Animals Antigens, CD1 - genetics Antigens, CD1 - metabolism Bronchial Hyperreactivity - genetics Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - metabolism Bronchial Hyperreactivity - microbiology Bronchial Hyperreactivity - physiopathology Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - microbiology Disease Models, Animal Gene Expression Regulation Immunity, Innate Interferon-gamma - deficiency Interferon-gamma - genetics Interleukin-4 - metabolism L-Lactate Dehydrogenase - metabolism Lung - immunology Lung - metabolism Lung - microbiology Lung - physiopathology Lung Diseases, Fungal - genetics Lung Diseases, Fungal - immunology Lung Diseases, Fungal - metabolism Lung Diseases, Fungal - microbiology Lung Diseases, Fungal - physiopathology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, SCID Natural Killer T-Cells - immunology Natural Killer T-Cells - metabolism Natural Killer T-Cells - microbiology Neutrophils - immunology Neutrophils - metabolism Neutrophils - microbiology Pneumocystis Infections - genetics Pneumocystis Infections - immunology Pneumocystis Infections - metabolism Pneumocystis Infections - microbiology Pneumocystis Infections - physiopathology Receptors, Interleukin-4 - deficiency Receptors, Interleukin-4 - genetics Receptors, Interleukin-8B - deficiency Receptors, Interleukin-8B - genetics Signal Transduction Species Specificity STAT6 Transcription Factor - deficiency STAT6 Transcription Factor - genetics STAT6 Transcription Factor - metabolism Time Factors Transcriptional Activation
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