Enterocyte Microvillus-Derived Vesicles Detoxify Bacterial Products and Regulate Epithelial-Microbial Interactions

The continuous monolayer of intestinal epithelial cells (IECs) lining the gut lumen functions as the site of nutrient absorption and as a physical barrier to prevent the translocation of microbes and associated toxic compounds into the peripheral vasculature [1]. IECs also express host defense prote...

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Veröffentlicht in:	Current biology 2012-04, Vol.22 (7), p.627-631
Hauptverfasser:	Shifrin, David A., McConnell, Russell E., Nambiar, Rajalakshmi, Higginbotham, James N., Coffey, Robert J., Tyska, Matthew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption alkaline phosphatase Alkaline Phosphatase - metabolism Animals bacteria Caco-2 Cells Cytoplasmic Vesicles - metabolism Cytoplasmic Vesicles - microbiology Cytoplasmic Vesicles - ultrastructure Enterocytes - cytology Enterocytes - metabolism Enteropathogenic Escherichia coli - growth & development Enteropathogenic Escherichia coli - immunology Enteropathogenic Escherichia coli - metabolism Epithelial Cells - immunology Escherichia coli Humans inflammation intestinal mucosa Intestine, Small - cytology Intestine, Small - metabolism Intestine, Small - microbiology lipopolysaccharides Lipopolysaccharides - metabolism Microscopy, Electron, Transmission microvilli Microvilli - metabolism Microvilli - microbiology Microvilli - ultrastructure Myosin Heavy Chains - metabolism Myosin Type I - metabolism pathogens population growth proteins Rats toxicity
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