Pharmacokinetics, Lymph Node Uptake, and Mechanistic PK Model of Near-Infrared Dye-Labeled Bevacizumab After IV and SC Administration in Mice

Our objective was to determine the pharmacokinetics, bioavailability and lymph node uptake of the monoclonal antibody bevacizumab, labeled with the near-infrared (IR) dye 800CW, after intravenous (IV) and subcutaneous (SC) administration in mice. Fluorescence imaging and enzyme-linked immunosorbent...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The AAPS journal 2012-06, Vol.14 (2), p.252-261
Hauptverfasser:	Wu, Fang, Tamhane, Mitalee, Morris, Marilyn E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - pharmacokinetics Bevacizumab Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Fluorescent Dyes - administration & dosage Fluorescent Dyes - pharmacokinetics Humans Injections, Intravenous Injections, Subcutaneous Lymph Nodes - drug effects Lymph Nodes - metabolism Male Mice Models, Biological Pharmacology/Toxicology Pharmacy Research Article Spectroscopy, Near-Infrared - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!