The impact of apheresis platelet manipulation on corrected count increment
BACKGROUND: Concentrating and washing apheresis platelets (APs) substantially reduce the number of allergic transfusion reactions likely due to removal of plasma. However, these processes may damage platelets (PLTs). This study evaluated whether concentrating or washing APs decrease the corrected co...
Gespeichert in:
| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2012-06, Vol.52 (6), p.1221-1227 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1227 |
|---|---|
| container_issue | 6 |
| container_start_page | 1221 |
| container_title | Transfusion (Philadelphia, Pa.) |
| container_volume | 52 |
| creator | Karafin, Matthew Fuller, Alice K. Savage, William J. King, Karen E. Ness, Paul M. Tobian, Aaron A.R. |
| description | BACKGROUND: Concentrating and washing apheresis platelets (APs) substantially reduce the number of allergic transfusion reactions likely due to removal of plasma. However, these processes may damage platelets (PLTs). This study evaluated whether concentrating or washing APs decrease the corrected count increment (CCI).
STUDY DESIGN AND METHODS: This retrospective study evaluated individuals who initially received unmanipulated APs and subsequently received concentrated and/or washed APs at a large university hospital between 1998 and 2009. Concentrated units were prepared by reducing the plasma volume of APs by a goal of more than 67%. Washed units were prepared by washing the APs with 1 L of normal saline. The CCI (PLTs [×106]× m2/L) for all transfusions was calculated. Hypothesis testing was performed with t tests for continuous variables and chi‐square tests for dichotomous variables.
RESULTS: We evaluated 121 individuals: 46 patients who received unmanipulated, concentrated, and then washed APs; 59 patients who received unmanipulated and then concentrated APs; and 16 patients who received unmanipulated and then washed APs. Patient demographics were similar among the three groups. The mean CCI for unmanipulated AP transfusions at 0 to 2 hours posttransfusion was significantly higher than concentrated and washed PLT transfusions (p |
| doi_str_mv | 10.1111/j.1537-2995.2011.03476.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3325359</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1020187297</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6086-116f19e313f0e1e66c7a6596a89e85cf5f821a5032f6b13caaf51f4549cb7b343</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0EotvCX0C5IHFJsD2xkxxAgooWUAEJFnEced0x6yVf2And_nu87LLADcuSx5rnnRm9w1gmeCHSebophIIql02jCsmFKDiUlS62d9jimLjLFpyXIhcC5Ak7jXHDOZcNF_fZiZQSAFS9YG-Xa8p8Nxo7ZYPLzLimQNHHbGzNRC1NWWd6P87p54c-S9cOIZCd6DpFcz9lvreBOuqnB-yeM22kh4f3jH2-eLU8f51ffbh8c_7iKrea1zrNo51oCAQ4ToK0tpXRqtGmbqhW1ilXS2EUB-n0SoA1xinhSlU2dlWtoIQz9nxfd5xXHV3b1DqYFsfgOxNucTAe_830fo1fhx8IIBWoJhV4cigQhu8zxQk7Hy21relpmCMKnjytK9lUCa33qA1DjIHcsY3guFsFbnDnOO4cx90q8NcqcJukj_4e8yj87X0CHh8AE61pXTC99fEPp7nQiuvEPdtzN76l2_8eAJcfL3ZR0ud7vY8TbY96E76hrqBS-OX9Jcrq08sS4B0K-AnnCrSB</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1020187297</pqid></control><display><type>article</type><title>The impact of apheresis platelet manipulation on corrected count increment</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Karafin, Matthew ; Fuller, Alice K. ; Savage, William J. ; King, Karen E. ; Ness, Paul M. ; Tobian, Aaron A.R.</creator><creatorcontrib>Karafin, Matthew ; Fuller, Alice K. ; Savage, William J. ; King, Karen E. ; Ness, Paul M. ; Tobian, Aaron A.R.</creatorcontrib><description>BACKGROUND: Concentrating and washing apheresis platelets (APs) substantially reduce the number of allergic transfusion reactions likely due to removal of plasma. However, these processes may damage platelets (PLTs). This study evaluated whether concentrating or washing APs decrease the corrected count increment (CCI).
STUDY DESIGN AND METHODS: This retrospective study evaluated individuals who initially received unmanipulated APs and subsequently received concentrated and/or washed APs at a large university hospital between 1998 and 2009. Concentrated units were prepared by reducing the plasma volume of APs by a goal of more than 67%. Washed units were prepared by washing the APs with 1 L of normal saline. The CCI (PLTs [×106]× m2/L) for all transfusions was calculated. Hypothesis testing was performed with t tests for continuous variables and chi‐square tests for dichotomous variables.
RESULTS: We evaluated 121 individuals: 46 patients who received unmanipulated, concentrated, and then washed APs; 59 patients who received unmanipulated and then concentrated APs; and 16 patients who received unmanipulated and then washed APs. Patient demographics were similar among the three groups. The mean CCI for unmanipulated AP transfusions at 0 to 2 hours posttransfusion was significantly higher than concentrated and washed PLT transfusions (p < 0.001). When accounting for PLT loss due to manipulation, concentrating APs did not impact the CCI. However, the CCI remained significantly lower for washed products at all time points after transfusion (40.7% mean reduction at 20‐24 hr, p < 0.001).
CONCLUSIONS: Washing APs significantly reduces PLT count recovery and survival, as demonstrated by a significantly reduced CCI.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2011.03476.x</identifier><identifier>PMID: 22233358</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood coagulation. Blood cells ; Blood Preservation - adverse effects ; Blood Preservation - methods ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Child ; Child, Preschool ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant ; Male ; Medical sciences ; Middle Aged ; Molecular and cellular biology ; Platelet ; Platelet Count - standards ; Platelet Transfusion - adverse effects ; Platelet Transfusion - methods ; Platelet Transfusion - standards ; Plateletpheresis - adverse effects ; Plateletpheresis - methods ; Research Design ; Retrospective Studies ; Specimen Handling - adverse effects ; Specimen Handling - methods ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Young Adult</subject><ispartof>Transfusion (Philadelphia, Pa.), 2012-06, Vol.52 (6), p.1221-1227</ispartof><rights>2012 American Association of Blood Banks</rights><rights>2015 INIST-CNRS</rights><rights>2012 American Association of Blood Banks.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6086-116f19e313f0e1e66c7a6596a89e85cf5f821a5032f6b13caaf51f4549cb7b343</citedby><cites>FETCH-LOGICAL-c6086-116f19e313f0e1e66c7a6596a89e85cf5f821a5032f6b13caaf51f4549cb7b343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2011.03476.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2011.03476.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26016506$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22233358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karafin, Matthew</creatorcontrib><creatorcontrib>Fuller, Alice K.</creatorcontrib><creatorcontrib>Savage, William J.</creatorcontrib><creatorcontrib>King, Karen E.</creatorcontrib><creatorcontrib>Ness, Paul M.</creatorcontrib><creatorcontrib>Tobian, Aaron A.R.</creatorcontrib><title>The impact of apheresis platelet manipulation on corrected count increment</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: Concentrating and washing apheresis platelets (APs) substantially reduce the number of allergic transfusion reactions likely due to removal of plasma. However, these processes may damage platelets (PLTs). This study evaluated whether concentrating or washing APs decrease the corrected count increment (CCI).
STUDY DESIGN AND METHODS: This retrospective study evaluated individuals who initially received unmanipulated APs and subsequently received concentrated and/or washed APs at a large university hospital between 1998 and 2009. Concentrated units were prepared by reducing the plasma volume of APs by a goal of more than 67%. Washed units were prepared by washing the APs with 1 L of normal saline. The CCI (PLTs [×106]× m2/L) for all transfusions was calculated. Hypothesis testing was performed with t tests for continuous variables and chi‐square tests for dichotomous variables.
RESULTS: We evaluated 121 individuals: 46 patients who received unmanipulated, concentrated, and then washed APs; 59 patients who received unmanipulated and then concentrated APs; and 16 patients who received unmanipulated and then washed APs. Patient demographics were similar among the three groups. The mean CCI for unmanipulated AP transfusions at 0 to 2 hours posttransfusion was significantly higher than concentrated and washed PLT transfusions (p < 0.001). When accounting for PLT loss due to manipulation, concentrating APs did not impact the CCI. However, the CCI remained significantly lower for washed products at all time points after transfusion (40.7% mean reduction at 20‐24 hr, p < 0.001).
CONCLUSIONS: Washing APs significantly reduces PLT count recovery and survival, as demonstrated by a significantly reduced CCI.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood Preservation - adverse effects</subject><subject>Blood Preservation - methods</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular and cellular biology</subject><subject>Platelet</subject><subject>Platelet Count - standards</subject><subject>Platelet Transfusion - adverse effects</subject><subject>Platelet Transfusion - methods</subject><subject>Platelet Transfusion - standards</subject><subject>Plateletpheresis - adverse effects</subject><subject>Plateletpheresis - methods</subject><subject>Research Design</subject><subject>Retrospective Studies</subject><subject>Specimen Handling - adverse effects</subject><subject>Specimen Handling - methods</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Young Adult</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EotvCX0C5IHFJsD2xkxxAgooWUAEJFnEced0x6yVf2And_nu87LLADcuSx5rnnRm9w1gmeCHSebophIIql02jCsmFKDiUlS62d9jimLjLFpyXIhcC5Ak7jXHDOZcNF_fZiZQSAFS9YG-Xa8p8Nxo7ZYPLzLimQNHHbGzNRC1NWWd6P87p54c-S9cOIZCd6DpFcz9lvreBOuqnB-yeM22kh4f3jH2-eLU8f51ffbh8c_7iKrea1zrNo51oCAQ4ToK0tpXRqtGmbqhW1ilXS2EUB-n0SoA1xinhSlU2dlWtoIQz9nxfd5xXHV3b1DqYFsfgOxNucTAe_830fo1fhx8IIBWoJhV4cigQhu8zxQk7Hy21relpmCMKnjytK9lUCa33qA1DjIHcsY3guFsFbnDnOO4cx90q8NcqcJukj_4e8yj87X0CHh8AE61pXTC99fEPp7nQiuvEPdtzN76l2_8eAJcfL3ZR0ud7vY8TbY96E76hrqBS-OX9Jcrq08sS4B0K-AnnCrSB</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Karafin, Matthew</creator><creator>Fuller, Alice K.</creator><creator>Savage, William J.</creator><creator>King, Karen E.</creator><creator>Ness, Paul M.</creator><creator>Tobian, Aaron A.R.</creator><general>Blackwell Publishing Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201206</creationdate><title>The impact of apheresis platelet manipulation on corrected count increment</title><author>Karafin, Matthew ; Fuller, Alice K. ; Savage, William J. ; King, Karen E. ; Ness, Paul M. ; Tobian, Aaron A.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6086-116f19e313f0e1e66c7a6596a89e85cf5f821a5032f6b13caaf51f4549cb7b343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood Preservation - adverse effects</topic><topic>Blood Preservation - methods</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular and cellular biology</topic><topic>Platelet</topic><topic>Platelet Count - standards</topic><topic>Platelet Transfusion - adverse effects</topic><topic>Platelet Transfusion - methods</topic><topic>Platelet Transfusion - standards</topic><topic>Plateletpheresis - adverse effects</topic><topic>Plateletpheresis - methods</topic><topic>Research Design</topic><topic>Retrospective Studies</topic><topic>Specimen Handling - adverse effects</topic><topic>Specimen Handling - methods</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karafin, Matthew</creatorcontrib><creatorcontrib>Fuller, Alice K.</creatorcontrib><creatorcontrib>Savage, William J.</creatorcontrib><creatorcontrib>King, Karen E.</creatorcontrib><creatorcontrib>Ness, Paul M.</creatorcontrib><creatorcontrib>Tobian, Aaron A.R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karafin, Matthew</au><au>Fuller, Alice K.</au><au>Savage, William J.</au><au>King, Karen E.</au><au>Ness, Paul M.</au><au>Tobian, Aaron A.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of apheresis platelet manipulation on corrected count increment</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2012-06</date><risdate>2012</risdate><volume>52</volume><issue>6</issue><spage>1221</spage><epage>1227</epage><pages>1221-1227</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: Concentrating and washing apheresis platelets (APs) substantially reduce the number of allergic transfusion reactions likely due to removal of plasma. However, these processes may damage platelets (PLTs). This study evaluated whether concentrating or washing APs decrease the corrected count increment (CCI).
STUDY DESIGN AND METHODS: This retrospective study evaluated individuals who initially received unmanipulated APs and subsequently received concentrated and/or washed APs at a large university hospital between 1998 and 2009. Concentrated units were prepared by reducing the plasma volume of APs by a goal of more than 67%. Washed units were prepared by washing the APs with 1 L of normal saline. The CCI (PLTs [×106]× m2/L) for all transfusions was calculated. Hypothesis testing was performed with t tests for continuous variables and chi‐square tests for dichotomous variables.
RESULTS: We evaluated 121 individuals: 46 patients who received unmanipulated, concentrated, and then washed APs; 59 patients who received unmanipulated and then concentrated APs; and 16 patients who received unmanipulated and then washed APs. Patient demographics were similar among the three groups. The mean CCI for unmanipulated AP transfusions at 0 to 2 hours posttransfusion was significantly higher than concentrated and washed PLT transfusions (p < 0.001). When accounting for PLT loss due to manipulation, concentrating APs did not impact the CCI. However, the CCI remained significantly lower for washed products at all time points after transfusion (40.7% mean reduction at 20‐24 hr, p < 0.001).
CONCLUSIONS: Washing APs significantly reduces PLT count recovery and survival, as demonstrated by a significantly reduced CCI.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>22233358</pmid><doi>10.1111/j.1537-2995.2011.03476.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1132 |
| ispartof | Transfusion (Philadelphia, Pa.), 2012-06, Vol.52 (6), p.1221-1227 |
| issn | 0041-1132 1537-2995 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3325359 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adolescent Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood coagulation. Blood cells Blood Preservation - adverse effects Blood Preservation - methods Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Child Child, Preschool Female Fundamental and applied biological sciences. Psychology Humans Infant Male Medical sciences Middle Aged Molecular and cellular biology Platelet Platelet Count - standards Platelet Transfusion - adverse effects Platelet Transfusion - methods Platelet Transfusion - standards Plateletpheresis - adverse effects Plateletpheresis - methods Research Design Retrospective Studies Specimen Handling - adverse effects Specimen Handling - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Young Adult |
| title | The impact of apheresis platelet manipulation on corrected count increment |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T22%3A37%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20impact%20of%20apheresis%20platelet%20manipulation%20on%20corrected%20count%20increment&rft.jtitle=Transfusion%20(Philadelphia,%20Pa.)&rft.au=Karafin,%20Matthew&rft.date=2012-06&rft.volume=52&rft.issue=6&rft.spage=1221&rft.epage=1227&rft.pages=1221-1227&rft.issn=0041-1132&rft.eissn=1537-2995&rft.coden=TRANAT&rft_id=info:doi/10.1111/j.1537-2995.2011.03476.x&rft_dat=%3Cproquest_pubme%3E1020187297%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1020187297&rft_id=info:pmid/22233358&rfr_iscdi=true |