Single Periocular Injection of Celecoxib-PLGA Microparticles Inhibits Diabetes-Induced Elevations in Retinal PGE2, VEGF, and Vascular Leakage

To determine whether celecoxib inhibits VEGF secretion from ARPE-19 cells and to investigate further the safety and effectiveness of periocular celecoxib-poly (lactide-co-glycolide; PLGA) microparticles in inhibiting elevations in retinal PGE(2), VEGF, and blood-tissue barrier leakage at the end of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigative ophthalmology & visual science 2006-03, Vol.47 (3), p.1149-1160
Hauptverfasser:	Amrite, Aniruddha C, Ayalasomayajula, Surya P, Cheruvu, Narayan P. S, Kompella, Uday B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Retinal Barrier - drug effects Capillary Permeability - drug effects Celecoxib Cell Culture Techniques Cyclooxygenase Inhibitors - administration & dosage Cyclooxygenase Inhibitors - pharmacology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - prevention & control Diabetic Retinopathy - metabolism Diabetic Retinopathy - prevention & control Dinoprostone - metabolism Drug Carriers Humans Injections Lactic Acid - administration & dosage Lactic Acid - pharmacology Male Microspheres Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - metabolism Polyglycolic Acid - administration & dosage Polyglycolic Acid - pharmacology Polymers - administration & dosage Polymers - pharmacology Pyrazoles - administration & dosage Pyrazoles - pharmacology Rats Rats, Sprague-Dawley Receptors, Vascular Endothelial Growth Factor - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Sulfonamides - administration & dosage Sulfonamides - pharmacology Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!