Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation

Follicular helper CD4 T (Tfh) cells provide B cells with signals that are important for the generation of high-affinity Abs and immunological memory and, therefore, are critical for the protective immunity elicited by most human vaccines. Transcriptional regulators of human Tfh cell differentiation...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-04, Vol.188 (8), p.3734-3744
Hauptverfasser:	Kroenke, Mark A, Eto, Danelle, Locci, Michela, Cho, Michael, Davidson, Terence, Haddad, Elias K, Crotty, Shane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Cell Communication Cell Differentiation Chemokines, CXC - genetics Chemokines, CXC - immunology Coculture Techniques DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology DNA-Binding Proteins - metabolism Gene Expression Regulation - immunology Germinal Center - cytology Germinal Center - immunology Humans Immunologic Memory Inducible T-Cell Co-Stimulator Protein - genetics Inducible T-Cell Co-Stimulator Protein - immunology Interleukins - genetics Lentivirus Mice Plasmids Protein Transport Proto-Oncogene Proteins c-bcl-6 Proto-Oncogene Proteins c-maf - genetics Proto-Oncogene Proteins c-maf - immunology Proto-Oncogene Proteins c-maf - metabolism Signal Transduction T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Transcription, Genetic Transfection
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