Electron Tomography Reveals Rab6 Is Essential to the Trafficking of trans‐Golgi Clathrin and COPI‐Coated Vesicles and the Maintenance of Golgi Cisternal Number

We have shown previously that Rab6, a small, trans‐Golgi‐localized GTPase, acts upstream of the conserved oligomeric Golgi complex (COG) and ZW10/RINT1 retrograde tether complexes to maintain Golgi homeostasis. In this article, we present evidence from the unbiased and high‐resolution approach of el...

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Veröffentlicht in:	Traffic (Copenhagen, Denmark) Denmark), 2012-05, Vol.13 (5), p.727-744
Hauptverfasser:	Storrie, Brian, Micaroni, Massimo, Morgan, Garry P., Jones, Nick, Kamykowski, Jeffrey A., Wilkins, Ngozi, Pan, Timothy H., Marsh, Brad J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport COP-Coated Vesicles - metabolism Electron Microscope Tomography - methods electron microscopy electron tomography Golgi Apparatus - metabolism Golgi cisternae Green Fluorescent Proteins - metabolism HeLa Cells Homeostasis Humans Image Processing, Computer-Assisted membrane traffic Microscopy, Electron - methods myosin II Myosin Type II - metabolism Phenotype Protein Isoforms Protein Transport rab GTP-Binding Proteins - metabolism Rab6 RNA, Small Interfering - metabolism three‐dimensional reconstruction Tomography trans-Golgi Network - metabolism transport vesicles VSV‐G
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