Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis
Background: The cytokinesis-block micronucleus test (MNT), as a marker of chromosomal mutagen sensitivity, was applied in a number of studies enrolling breast cancer (BC) patients and subjects with known or putative genetic predisposition to BC. The large majority of them involve the evaluation of i...
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| Veröffentlicht in: | British journal of cancer 2012-02, Vol.106 (4), p.780-790 |
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| creator | Cardinale, F Bruzzi, P Bolognesi, C |
| description | Background:
The cytokinesis-block micronucleus test (MNT), as a marker of chromosomal mutagen sensitivity, was applied in a number of studies enrolling breast cancer (BC) patients and subjects with known or putative genetic predisposition to BC. The large majority of them involve the evaluation of induced micronuclei (MN) frequency in peripheral lymphocytes, after the
in vitro
challenge with ionising radiations.
Methods:
The aim of the present systematic review and meta-analysis is to investigate the role of MN assay in the identification of individuals at increased risk of BC and its potential use as prescreening test in women with a family history (FH) of BC.
Results:
Twelve studies were included in the meta-analysis, covering a time interval 1998–2007, and including 752 cases and 593 controls. Among the cases, 629 are cancer patients and 123 are cancer-free subjects, including 32 first-degree relatives of the susceptible subjects and 91 BRCA1/2 mutation carriers. Our meta-analysis reveals a significant increase of baseline MN frequency related to cancer status, but the association with FH of BC and specifically with BRCA mutations is not clear. A larger difference in MN frequency between cases and controls was observed after
in vitro
challenge, but response to radiation exposure doesn't appear to better discriminate cancer-susceptible subjects.
Conclusion:
Our study suggests the presence of some bias affecting many of these studies, reinforcing the suggestion that a more rigorous study design is needed in this area. |
| doi_str_mv | 10.1038/bjc.2011.567 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3324300</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2586273161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-922bdb8bd64eba5c9dde01c171d11c414950eee4263ac7c4d4cc1c57a047a2203</originalsourceid><addsrcrecordid>eNptkc2LFDEQxYO4uOPqzbMEwZs9Jun0pONBkMWPhQVB9ByqKzVjxv4Yk_TK_PebYcZdFzyFpH68V3mPsRdSLKWo27fdFpdKSLlsVuYRW8imVpVslXnMFkIIUwmrxDl7mtK2XK1ozRN2rpRsjajNgv36NvXEpzUfAsZpnLGnOfFMKfMw8l0kHzCHccO7SFAeEUakyNOckHY5dKEPef-OA0_7lGmAHJBHugn0h8Po-UAZKhih36eQnrGzNfSJnp_OC_bj08fvl1-q66-fry4_XFeoTZsrq1Tnu7bzK00dNGi9JyFRGumlRC21bQQRabWqAQ1qrxElNgaENqCUqC_Y-6Pubu4G8khjjtC7XQwDxL2bILiHkzH8dJvpxtW10rU4CLw6CcTp91yycNtpjuUXyVklGymttQV6c4RKbilFWt8ZSOEOzbjSjDs040ozBX_571J38N8qCvD6BEBC6NexJB3SPdesrLHi4FsduVRG44bi_XL_Nb4F9OmofA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>921511999</pqid></control><display><type>article</type><title>Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Cardinale, F ; Bruzzi, P ; Bolognesi, C</creator><creatorcontrib>Cardinale, F ; Bruzzi, P ; Bolognesi, C</creatorcontrib><description>Background:
The cytokinesis-block micronucleus test (MNT), as a marker of chromosomal mutagen sensitivity, was applied in a number of studies enrolling breast cancer (BC) patients and subjects with known or putative genetic predisposition to BC. The large majority of them involve the evaluation of induced micronuclei (MN) frequency in peripheral lymphocytes, after the
in vitro
challenge with ionising radiations.
Methods:
The aim of the present systematic review and meta-analysis is to investigate the role of MN assay in the identification of individuals at increased risk of BC and its potential use as prescreening test in women with a family history (FH) of BC.
Results:
Twelve studies were included in the meta-analysis, covering a time interval 1998–2007, and including 752 cases and 593 controls. Among the cases, 629 are cancer patients and 123 are cancer-free subjects, including 32 first-degree relatives of the susceptible subjects and 91 BRCA1/2 mutation carriers. Our meta-analysis reveals a significant increase of baseline MN frequency related to cancer status, but the association with FH of BC and specifically with BRCA mutations is not clear. A larger difference in MN frequency between cases and controls was observed after
in vitro
challenge, but response to radiation exposure doesn't appear to better discriminate cancer-susceptible subjects.
Conclusion:
Our study suggests the presence of some bias affecting many of these studies, reinforcing the suggestion that a more rigorous study design is needed in this area.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2011.567</identifier><identifier>PMID: 22187037</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biological and medical sciences ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - genetics ; Cancer Research ; DNA repair ; Drug Resistance ; Epidemiology ; Family Health ; Family medical history ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetics and Genomics ; Gynecology. Andrology. Obstetrics ; Humans ; Lymphocytes ; Mammary gland diseases ; Medical research ; Medical sciences ; Meta-analysis ; Micronucleus Tests - methods ; Molecular Medicine ; Mutation ; Oncology ; Radiation ; Systematic review ; Tumors</subject><ispartof>British journal of cancer, 2012-02, Vol.106 (4), p.780-790</ispartof><rights>The Author(s) 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Feb 14, 2012</rights><rights>Copyright © 2012 Cancer Research UK 2012 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-922bdb8bd64eba5c9dde01c171d11c414950eee4263ac7c4d4cc1c57a047a2203</citedby><cites>FETCH-LOGICAL-c478t-922bdb8bd64eba5c9dde01c171d11c414950eee4263ac7c4d4cc1c57a047a2203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324300/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324300/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25697909$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22187037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cardinale, F</creatorcontrib><creatorcontrib>Bruzzi, P</creatorcontrib><creatorcontrib>Bolognesi, C</creatorcontrib><title>Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
The cytokinesis-block micronucleus test (MNT), as a marker of chromosomal mutagen sensitivity, was applied in a number of studies enrolling breast cancer (BC) patients and subjects with known or putative genetic predisposition to BC. The large majority of them involve the evaluation of induced micronuclei (MN) frequency in peripheral lymphocytes, after the
in vitro
challenge with ionising radiations.
Methods:
The aim of the present systematic review and meta-analysis is to investigate the role of MN assay in the identification of individuals at increased risk of BC and its potential use as prescreening test in women with a family history (FH) of BC.
Results:
Twelve studies were included in the meta-analysis, covering a time interval 1998–2007, and including 752 cases and 593 controls. Among the cases, 629 are cancer patients and 123 are cancer-free subjects, including 32 first-degree relatives of the susceptible subjects and 91 BRCA1/2 mutation carriers. Our meta-analysis reveals a significant increase of baseline MN frequency related to cancer status, but the association with FH of BC and specifically with BRCA mutations is not clear. A larger difference in MN frequency between cases and controls was observed after
in vitro
challenge, but response to radiation exposure doesn't appear to better discriminate cancer-susceptible subjects.
Conclusion:
Our study suggests the presence of some bias affecting many of these studies, reinforcing the suggestion that a more rigorous study design is needed in this area.</description><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Cancer Research</subject><subject>DNA repair</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Family Health</subject><subject>Family medical history</subject><subject>Female</subject><subject>Genes, BRCA1</subject><subject>Genes, BRCA2</subject><subject>Genetics and Genomics</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Mammary gland diseases</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Meta-analysis</subject><subject>Micronucleus Tests - methods</subject><subject>Molecular Medicine</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Radiation</subject><subject>Systematic review</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkc2LFDEQxYO4uOPqzbMEwZs9Jun0pONBkMWPhQVB9ByqKzVjxv4Yk_TK_PebYcZdFzyFpH68V3mPsRdSLKWo27fdFpdKSLlsVuYRW8imVpVslXnMFkIIUwmrxDl7mtK2XK1ozRN2rpRsjajNgv36NvXEpzUfAsZpnLGnOfFMKfMw8l0kHzCHccO7SFAeEUakyNOckHY5dKEPef-OA0_7lGmAHJBHugn0h8Po-UAZKhih36eQnrGzNfSJnp_OC_bj08fvl1-q66-fry4_XFeoTZsrq1Tnu7bzK00dNGi9JyFRGumlRC21bQQRabWqAQ1qrxElNgaENqCUqC_Y-6Pubu4G8khjjtC7XQwDxL2bILiHkzH8dJvpxtW10rU4CLw6CcTp91yycNtpjuUXyVklGymttQV6c4RKbilFWt8ZSOEOzbjSjDs040ozBX_571J38N8qCvD6BEBC6NexJB3SPdesrLHi4FsduVRG44bi_XL_Nb4F9OmofA</recordid><startdate>20120214</startdate><enddate>20120214</enddate><creator>Cardinale, F</creator><creator>Bruzzi, P</creator><creator>Bolognesi, C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20120214</creationdate><title>Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis</title><author>Cardinale, F ; Bruzzi, P ; Bolognesi, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-922bdb8bd64eba5c9dde01c171d11c414950eee4263ac7c4d4cc1c57a047a2203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Cancer Research</topic><topic>DNA repair</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Family Health</topic><topic>Family medical history</topic><topic>Female</topic><topic>Genes, BRCA1</topic><topic>Genes, BRCA2</topic><topic>Genetics and Genomics</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Lymphocytes</topic><topic>Mammary gland diseases</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Meta-analysis</topic><topic>Micronucleus Tests - methods</topic><topic>Molecular Medicine</topic><topic>Mutation</topic><topic>Oncology</topic><topic>Radiation</topic><topic>Systematic review</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cardinale, F</creatorcontrib><creatorcontrib>Bruzzi, P</creatorcontrib><creatorcontrib>Bolognesi, C</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cardinale, F</au><au>Bruzzi, P</au><au>Bolognesi, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2012-02-14</date><risdate>2012</risdate><volume>106</volume><issue>4</issue><spage>780</spage><epage>790</epage><pages>780-790</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
The cytokinesis-block micronucleus test (MNT), as a marker of chromosomal mutagen sensitivity, was applied in a number of studies enrolling breast cancer (BC) patients and subjects with known or putative genetic predisposition to BC. The large majority of them involve the evaluation of induced micronuclei (MN) frequency in peripheral lymphocytes, after the
in vitro
challenge with ionising radiations.
Methods:
The aim of the present systematic review and meta-analysis is to investigate the role of MN assay in the identification of individuals at increased risk of BC and its potential use as prescreening test in women with a family history (FH) of BC.
Results:
Twelve studies were included in the meta-analysis, covering a time interval 1998–2007, and including 752 cases and 593 controls. Among the cases, 629 are cancer patients and 123 are cancer-free subjects, including 32 first-degree relatives of the susceptible subjects and 91 BRCA1/2 mutation carriers. Our meta-analysis reveals a significant increase of baseline MN frequency related to cancer status, but the association with FH of BC and specifically with BRCA mutations is not clear. A larger difference in MN frequency between cases and controls was observed after
in vitro
challenge, but response to radiation exposure doesn't appear to better discriminate cancer-susceptible subjects.
Conclusion:
Our study suggests the presence of some bias affecting many of these studies, reinforcing the suggestion that a more rigorous study design is needed in this area.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22187037</pmid><doi>10.1038/bjc.2011.567</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Biomarkers Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Cancer Research DNA repair Drug Resistance Epidemiology Family Health Family medical history Female Genes, BRCA1 Genes, BRCA2 Genetics and Genomics Gynecology. Andrology. Obstetrics Humans Lymphocytes Mammary gland diseases Medical research Medical sciences Meta-analysis Micronucleus Tests - methods Molecular Medicine Mutation Oncology Radiation Systematic review Tumors |
| title | Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis |
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