A Caveolae-Targeted L-Type Ca2+ Channel Antagonist Inhibits Hypertrophic Signaling Without Reducing Cardiac Contractility

RATIONALE:The source of Ca to activate pathological cardiac hypertrophy is not clearly defined. Ca influx through the L-type Ca channels (LTCCs) determines “contractile” Ca, which is not thought to be the source of “hypertrophic” Ca. However, some LTCCs are housed in caveolin-3 (Cav-3)–enriched sign...

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Veröffentlicht in:	Circulation research 2012-03, Vol.110 (5), p.669-674
Hauptverfasser:	Makarewich, Catherine A, Correll, Robert N, Gao, Hui, Zhang, Hongyu, Yang, Baohua, Berretta, Remus M, Rizzo, Victor, Molkentin, Jeffery D, Houser, Steven R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium channels Calcium channels (L-type) Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - metabolism Calcium influx Calcium signalling Cardiomyopathy, Hypertrophic - pathology Cardiomyopathy, Hypertrophic - physiopathology Cats Caveolae Caveolae - drug effects Caveolae - metabolism Caveolin Caveolin 3 - metabolism Cell Nucleus - metabolism Cells, Cultured Disease Models, Animal Fundamental and applied biological sciences. Psychology Heart Houses Hypertrophy Lymphocytes T Muscle contraction Myocardial Contraction - drug effects Myocardial Contraction - physiology Myocytes Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology NF-AT protein NFATC Transcription Factors - metabolism Nuclear transport Receptors, Adrenergic, beta-2 - drug effects Signal Transduction - drug effects Signal Transduction - physiology Vertebrates: cardiovascular system
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