Imaging Therapeutic PARP Inhibition In Vivo through Bioorthogonally Developed Companion Imaging Agents

A number of small-molecule poly (ADP-ribose) polymerase (PARP) inhibitors are currently undergoing advanced clinical trials. Determining the distribution and target inhibitory activity of these drugs in individual subjects, however, has proven problematic. Here, we used a PARP agent for positron emi...

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Veröffentlicht in:	Neoplasia (New York, N.Y.) N.Y.), 2012-03, Vol.14 (3), p.169-IN3
Hauptverfasser:	Reiner, Thomas, Lacy, Jessica, Keliher, Edmund J, Yang, Katherine S, Ullal, Adeeti, Kohler, Rainer H, Vinegoni, Claudio, Weissleder, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalytic Domain Cell Line, Tumor Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Humans Mice Mice, Inbred C57BL Mice, Nude Models, Molecular Molecular Imaging Multimodal Imaging Neoplasms - diagnosis Neoplasms - drug therapy Oncology Phthalazines - chemistry Phthalazines - metabolism Phthalazines - pharmacology Piperazines - chemistry Piperazines - metabolism Piperazines - pharmacology Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - chemistry Positron-Emission Tomography Protein Binding Protein Conformation Radiopharmaceuticals - chemistry Radiopharmaceuticals - metabolism Radiopharmaceuticals - pharmacology Tomography, X-Ray Computed
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