Bacterial persistence increases as environmental fitness decreases

Summary Since persister cells cause chronic infections and since Escherichia coli toxin MqsR increases persisters, we used protein engineering to increase the toxicity of MqsR to gain insights into persister cell formation. Through two amino acid replacements that increased the stability of MqsR, to...

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Veröffentlicht in:	Microbial biotechnology 2012-07, Vol.5 (4), p.509-522
Hauptverfasser:	Hong, Seok Hoon, Wang, Xiaoxue, O'Connor, Hazel F., Benedik, Michael J., Wood, Thomas K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid resistance Acids - toxicity Amino Acid Substitution Amino acids Antibiotics Bacterial infections Bacterial Proteins - genetics Biofilms Clonal deletion Corrosion resistance DNA microarrays E coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli - pathogenicity Escherichia coli - physiology Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Escherichia coli Proteins - toxicity Gene Deletion Gene expression Gene Expression Profiling Genes Hydrogen peroxide Manufacturing cells Microarray Analysis Microbial Viability - drug effects Motility Multidrug resistance Mutant Proteins - genetics Mutant Proteins - metabolism Mutant Proteins - toxicity Oxidants - toxicity Physiology Protein engineering Proteins Sigma Factor - genetics Stress response Toxicity Toxins
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