Structure of Geranyl Diphosphate C-Methyltransferase from Streptomyces coelicolor and Implications for the Mechanism of Isoprenoid Modification

Geranyl diphosphate C-methyltransferase (GPPMT) from Streptomyces coelicolor A3(2) is the first methyltransferase discovered that modifies an acyclic isoprenoid diphosphate, geranyl diphosphate (GPP), to yield a noncanonical acyclic allylic diphosphate product, 2-methylgeranyl diphosphate, which ser...

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Veröffentlicht in:	Biochemistry (Easton) 2012-04, Vol.51 (14), p.3003-3010
Hauptverfasser:	Köksal, Mustafa, Chou, Wayne K. W, Cane, David E, Christianson, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - metabolism Binding Sites Crystallography, X-Ray Diphosphates - chemistry Diphosphates - metabolism Diterpenes - chemistry Diterpenes - metabolism Methylation Methyltransferases - chemistry Methyltransferases - metabolism Protein Conformation S-Adenosylmethionine - metabolism Streptomyces coelicolor Streptomyces coelicolor - enzymology Streptomyces coelicolor - metabolism
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