Transporter-mediated protection against thiopurine-induced hematopoietic toxicity

Thiopurines are effective immunosuppressants and anticancer agents, but intracellular accumulation of their active metabolites (6-thioguanine nucleotides, 6-TGN) causes dose-limiting hematopoietic toxicity. Thiopurine S-methyltransferase deficiency is known to exacerbate thiopurine toxicity. However...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-07, Vol.68 (13), p.4983-4989
Hauptverfasser:	Krishnamurthy, Partha, Schwab, Matthias, Takenaka, Kazumasa, Nachagari, Deepa, Morgan, Jessica, Leslie, Mark, Du, Weinan, Boyd, Kelli, Cheok, Meyling, Nakauchi, Hiromitsu, Marzolini, Catia, Kim, Richard B, Poonkuzhali, Balasubramanian, Schuetz, Erin, Evans, William, Relling, Mary, Schuetz, John D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Cell Membrane - metabolism Cells, Cultured Cytoprotection - drug effects Cytoprotection - genetics Drug Resistance, Neoplasm - genetics Hematologic Diseases - chemically induced Hematologic Diseases - mortality Hematopoiesis - drug effects Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Membrane Transport Proteins - physiology Mercaptopurine - adverse effects Mercaptopurine - pharmacology Mercaptopurine - therapeutic use Mice Mice, Knockout Models, Biological Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Multidrug Resistance-Associated Proteins - physiology Polymorphism, Single Nucleotide - physiology Purines - adverse effects Purines - chemistry Purines - therapeutic use Sulfhydryl Compounds - adverse effects Sulfhydryl Compounds - therapeutic use Survival Analysis Tissue Distribution
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