Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid

Bioactive mediators derived from omega-3 eicosapentaenoic acid (EPA) elicit potent anti-inflammatory actions. Here, we identified novel EPA metabolites, including 8,18-dihydroxyeicosapentaenoic acid (8,18-diHEPE), 11,18-diHEPE, 12,18-diHEPE, and 17,18-diHEPE from 18-HEPE. Unlike resolvins E1 and E2,...

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Veröffentlicht in:	The Journal of biological chemistry 2012-03, Vol.287 (13), p.10525-10534
Hauptverfasser:	Isobe, Yosuke, Arita, Makoto, Matsueda, Shinnosuke, Iwamoto, Ryo, Fujihara, Takuji, Nakanishi, Hiroki, Taguchi, Ryo, Masuda, Koji, Sasaki, Kenji, Urabe, Daisuke, Inoue, Masayuki, Arai, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonate 12-Lipoxygenase - metabolism Arachidonate 15-Lipoxygenase - metabolism Docosahexaenoic Acids - metabolism Eosinophils - metabolism Fatty Acid Metabolism Female HEK293 Cells Humans Inflammation Inflammation Mediators - metabolism Lipids Lipoxygenase Pathway Magnetic Resonance Spectroscopy Male Metabolomics Molecular Structure Neutrophil Neutrophils - metabolism Peritonitis - chemically induced Peritonitis - metabolism Polyunsaturated Fatty Acids Zymosan - toxicity
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