Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

Leukaemia-linked gene mutations Analysis of the genomes of four patients with chronic lymphocytic leukaemia, and validation in more than 300 patients, has identified four genes — NOTCH1 , MYD88 , XPO1 and KLHL6 — that are recurrently mutated in the condition. Mutations in NOTCH1 , MYD88 and XPO1 are...

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Veröffentlicht in:	Nature (London) 2011-07, Vol.475 (7354), p.101-105
Hauptverfasser:	Puente, Xose S., Pinyol, Magda, Quesada, Víctor, Conde, Laura, Ordóñez, Gonzalo R., Villamor, Neus, Escaramis, Georgia, Jares, Pedro, Beà, Sílvia, González-Díaz, Marcos, Bassaganyas, Laia, Baumann, Tycho, Juan, Manel, López-Guerra, Mónica, Colomer, Dolors, Tubío, José M. C., López, Cristina, Navarro, Alba, Tornador, Cristian, Aymerich, Marta, Rozman, María, Hernández, Jesús M., Puente, Diana A., Freije, José M. P., Velasco, Gloria, Gutiérrez-Fernández, Ana, Costa, Dolors, Carrió, Anna, Guijarro, Sara, Enjuanes, Anna, Hernández, Lluís, Yagüe, Jordi, Nicolás, Pilar, Romeo-Casabona, Carlos M., Himmelbauer, Heinz, Castillo, Ester, Dohm, Juliane C., de Sanjosé, Silvia, Piris, Miguel A., de Alava, Enrique, Miguel, Jesús San, Royo, Romina, Gelpí, Josep L., Torrents, David, Orozco, Modesto, Pisano, David G., Valencia, Alfonso, Guigó, Roderic, Bayés, Mónica, Heath, Simon, Gut, Marta, Klatt, Peter, Marshall, John, Raine, Keiran, Stebbings, Lucy A., Futreal, P. Andrew, Stratton, Michael R., Campbell, Peter J., Gut, Ivo, López-Guillermo, Armando, Estivill, Xavier, Montserrat, Emili, López-Otín, Carlos, Campo, Elías
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/514/1948 631/208/737 692/699/67/1990/283/1895 Amino Acid Sequence Animals Biological and medical sciences Cancer Care and treatment Carrier Proteins - genetics Chronic lymphocytic leukemia DNA Mutational Analysis Exportin 1 Protein Flow cytometry Gene mutations Genetic aspects Genoma humà Genome, Human - genetics Genomes Hematologic and hematopoietic diseases Humanities and Social Sciences Humans Karyopherins - genetics letter Leucèmia limfocítica crònica Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Molecular Sequence Data multidisciplinary Mutagènesi Mutation Mutation - genetics Myeloid Differentiation Factor 88 - chemistry Myeloid Differentiation Factor 88 - genetics Nucleotide sequence Phosphorylation Physiological aspects Polymerase chain reaction Proteins Receptor, Notch1 - genetics Receptors, Cytoplasmic and Nuclear - genetics Reproducibility of Results Science Science (multidisciplinary) Studies
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