Incomplete chromatin condensation in enlarged rat myelocytic leukemia cells

The distinguishable morphologic features of nuclei of acute myelogenous leukemia cells with enlarged size and finely distributed nuclear chromatin indicate incomplete chromosome condensation that can be related to elevated gene expression. To confirm this, interphase chromosome structures were studi...

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Veröffentlicht in:	DNA and cell biology 2012-04, Vol.31 (4), p.470-478
Hauptverfasser:	Trencsenyi, Gyorgy, Nagy, Gabor, Bako, Fruzsina, Kertai, Pal, Banfalvi, Gaspar
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene Acute myeloid leukemia Animals Cell cycle Cell Line, Tumor Chromatin Chromatin Assembly and Disassembly - physiology Chromosomes Chromosomes, Mammalian - ultrastructure Condensation Female Gene expression Gene Expression Regulation, Neoplastic - physiology Indoles Interphase Interphase - physiology Leukemia, Myeloid - physiopathology Metaphase Microscopy, Fluorescence Models, Biological Myeloid leukemia Myelomonocytic leukemia Nuclei Original s Rats Rats, Long-Evans Supercoiling
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