Early mammalian erythropoiesis requires the Dot1L methyltransferase

Histone methylation is an important regulator of gene expression; its coordinated activity is critical in complex developmental processes such as hematopoiesis. Disruptor of telomere silencing 1-like (DOT1L) is a unique histone methyltransferase that specifically methylates histone H3 at lysine 79....

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Veröffentlicht in:	Blood 2010-11, Vol.116 (22), p.4483-4491
Hauptverfasser:	Feng, Yi, Yang, Yanping, Ortega, Manoela M., Copeland, Jessica N., Zhang, Mingcai, Jacob, Jennifer B., Fields, Timothy A., Vivian, Jay L., Fields, Patrick E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Cell Cycle Cells, Cultured Embryo, Mammalian - cytology Embryo, Mammalian - embryology Embryo, Mammalian - pathology Erythropoiesis Female GATA2 Transcription Factor - genetics Gene Expression Regulation, Developmental Hematologic and hematopoietic diseases Hematopoiesis Hematopoiesis and Stem Cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Histone-Lysine N-Methyltransferase Histones - metabolism Medical sciences Methylation Methyltransferases - genetics Methyltransferases - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mutation Proto-Oncogene Proteins - genetics Trans-Activators - genetics Transcription, Genetic Yolk Sac - cytology Yolk Sac - metabolism
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